SearchSkip to Search Results
- 1Bekele, Raie T.
- 1Benesch, Matthew
- 1Bravo, David M.
- 1Brindley, David N.
- 1Cozens, Greg
- 1Curtis, Jonathan M.
Structural variant detection by large-scale sequencing reveals new evolutionary evidence on breed divergence between Chinese and European pigsDownload
In this study, we performed a genome-wide SV detection among the genomes of thirteen pigs from diverse Chinese and European originated breeds by next genetation sequencing, and constrcuted a single-nucleotide resolution map involving 56,930 putative SVs. We firstly identified a SV hotspot...
Oxidative stress mediates estrogen receptor independent killing and contributes to tamoxifen resistanceDownload
Tamoxifen is the accepted therapy for patients with estrogen receptor-α (ERα)-positive breast cancer. However, clinical resistance to tamoxifen, as demonstrated by recurrence or progression on therapy, is frequent and precedes death from metastases. To improve breast cancer treatment it is vital...
Roles of small RNAs in the effects of nutrition on apoptosis and spermatogenesis in the adult testisDownload
We tested whether reductions in spermatozoal quality induced by under-nutrition are associated with increased germ cell apoptosis and disrupted spermatogenesis, and whether these effects are mediated by small RNAs. Groups of 8 male sheep were fed for a 10% increase or 10% decrease in body mass...
Phytonutrient diet supplementation promotes beneficial Clostridia species and intestinal mucus secretion resulting in protection against enteric infectionDownload
Plant extracts, or phytonutrients, are used in traditional medicine practices as supplements to enhance the immune system and gain resistance to various infectious diseases and are used in animal production as health promoting feed additives. To date, there are no studies that have assessed their...
Background The domestic pig is an important livestock species and there is strong interest in the factors that affect the development of viable embryos and offspring in this species. A limited understanding of the molecular mechanisms involved in early embryonic development has inhibited our...