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Skip to Search Results- 6Gene therapy
- 2Cationic polymers
- 2Transfection
- 1Adenovirus
- 1Antithrombotic polymers
- 1Bone marrow stromal cells
- 1Benjaminy, Shelly
- 1Bubela, Tania
- 1Hsu, Charlie Yu Ming
- 1Incani Ramirez, Vanessa
- 1Meneksedag Erol, Deniz
- 1Miklavcic, John
- 1Clandinin, M Tom (Agricultural, Food and Nutritional Science)
- 1Hasan Uludag
- 1Lavasanifar, Afsaneh (Pharmacy and Pharmaceutical Sciences)
- 1Tang, Tian (Department of Mechanical Engineering, Department of Biomedical Engineering)
- 1Uludag, Hasan (Chemical and Materials Engineering)
- 1Uludag, Hasan (Deparment of Chemical and Materials Engineering, Department of Biomedical Engineering)
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Ocular Gene Transfer in the Spotlight: Implications of Newspaper Content for Clinical Communications
Download2014-10-24
Bubela, Tania, Benjaminy, Shelly
Background Ocular gene transfer clinical trials are raising hopes for blindness treatments and attracting media attention. News media provide an accessible health information source for patients and the public, but are often criticized for overemphasizing benefits and underplaying risks of novel...
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Mechanistic studies on the uptake and intracellular trafficking of DNA complexes in primary cells using lipid-modified cationic polymers as non-viral gene carrier
DownloadFall 2012
This thesis work is aimed at addressing some of the fundamental questions surrounding the intracellular fate of plasmid DNA in clinically-relevant primary cells, when delivered with lipid-modi!ed cationic polymers as gene carriers. We developed an optimized procedure for the transfection of...
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Spring 2011
This thesis explores the capabilities of cationic polymers modified with lipids of different carbon chain length to deliver DNA molecules to primary cells and transformed cell lines. Our studies focus on two different polymers: polyethylenimine (PEI) and poly(L-lysine) (PLL). Firstly, PEI and PLL...
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Ganglioside Increases Metastatic Potential and Susceptibility of Prostate Cancer to Gene Therapy in vitro
DownloadFall 2009
Prostate cancer (CaP) is the 2nd most common cancer in North American men. Tumour management strategies are appropriate for early stage disease, but advanced disease has a poor prognosis and requires prompt treatment. Therefore, research into delay of tumour progression and efficacious treatment...
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A Combined Computational and Experimental Investigation of Polynucleotide Binding Polymers for Therapeutic Applications
DownloadFall 2017
Polynucleotide binding polymers have a wide range of therapeutic applications including delivery systems for therapeutic polynucleotides, and antithrombotic drugs for extracellular nucleic acid-mediated thrombogenic events. This dissertation explores polynucleotide binding polymers in these two...