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Skip to Search Results- 1Fagan-Garcia, Katharine
- 1Griffiths, Cameron
- 1Hou, Shangmei
- 1Jensen, Lionel D
- 1Marcet, Candy
- 1Reid, Colleen R.
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Herpes Simplex Virus Requires VP11/12 to Activate Src Family Kinase-PI3 Kinase-Akt Signalling
DownloadFall 2010
This thesis defines a novel role for the Herpes Simplex Virus (HSV) tegument protein, virion protein (VP) 11/12 as a modulator of host cell signalling. Studies aimed at examining infection induced lymphocyte inactivation, revealed that VP11/12 is tyrosine phosphorylated in three lymphocyte...
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Epithelial and vascular progenitors in the developing lung: Newer insights and therapeutic implications
DownloadFall 2012
Stanislaus Alphonse, Anthuvan Rajesh
Bronchopulmonary dysplasia (BPD) and congenital diaphragmatic hernia (CDH) are life-threatening lung diseases affecting newborn infants. Both diseases are characterized by impaired lung development and are currently untreatable. Dysregulation in the number or function of lung progenitor cells is...
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Fall 2010
Mast cells are immune cells important in innate immunity. Besides their role in asthma and allergies, mast cells are critical effector cells against various pathogens. Mast cells are established to be protective against bacterial infections, but little is known about their functions in viral...
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A large deletion virus reveals the presence of previously uncharacterized vaccinia virus inhibitors of NF-kB signaling
DownloadFall 2010
The classical Nuclear Factor kappa B (NF-κB) signaling pathway is an important regulator of inflammation and innate immune responses. Poxviruses, including vaccinia virus, encode multiple immune evasion proteins, including a growing number of NF-κB inhibitors. To determine if additional vaccinia...
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Fall 2017
Flaviviruses are important human pathogens that have an enormous impact on global health. Examples that have been studied in my research include dengue virus (DENV), West Nile virus (WNV) and most recently, Zika virus (ZIKV). Currently, there are very few vaccines against or therapeutic...
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Spring 2020
Respiratory syncytial virus (RSV) is a ubiquitous respiratory pathogen that infects almost everyone by the age of two. In high-risk populations, such as infants and elderly individuals, RSV can infect the lower respiratory tract and cause severe symptoms, such as bronchiolitis or pneumonia. As a...
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Fall 2021
Poxviruses encode many genes that are orthologs of cellular genes. These orthologs serve many functions, but those that are of most interest are ones that have evolved further and now serve an immune-evasion function. Such genes were likely first acquired by poxviruses through some form of...
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Fall 2020
Infectious respiratory diseases, caused by viruses and bacteria that attack the respiratory system, constitute a serious threat in public health around the world. Pathogens can be transmitted in the air though large droplets or aerosols. As aerosols can linger in the environment for a prolonged...
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Inhibition and enhancement of Respiratory Syncytial Virus replication by nucleoside analogues and bis(indole) compounds
DownloadSpring 2019
Respiratory syncytial virus (RSV) is an Orthopneumovirus that infects the epithelium of the airways. Severe RSV infection of the lower respiratory tract in infants is a leading cause of pediatric hospitalizations. RSV also causes substantial morbidity in immunocompromised and elderly populations....