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- 2Miyashita, Tetsuto
- 1Adams, Emily
- 1Bird, Heather M
- 1Byers, Kaylee A.
- 1Clarke, Bryan
- 1Clifford, Alexander M
- 20Department of Biological Sciences
- 4Department of Cell Biology
- 1Centre for Neuroscience
- 1Department of Botany
- 1Department of Computing Science
- 1Department of Medical Microbiology and Immunology
Smallpox was eradicated using vaccinia viruses (VACV) as vaccines, including Dryvax, a calf-lymph vaccine derived from the New York City Board of Health (NYCBH) strain, and TianTan, a chicken egg cultured vaccine used exclusively in China. To take advantage of the next generation sequencing...
Understanding the evolution of the membrane trafficking system in diverse eukaryotes through comparative genomics and transcriptomicsDownload
Single-celled organisms represent the majority of eukaryotic diversity. Recent advances in sequencing technologies have been critical for understanding the evolutionary biology and cell biology of microbial eukaryotes. Comparative genomic analyses have shown that many genes that underlie...
Transferrin is an evolutionary conserved protein that in addition to having a critical role in iron transport also has been shown to have a crucial role in host defence. Transferrin has been shown to sequester iron from invading pathogens, act directly against microbial pathogens, and is an...
Three species of Cretaceous marine squamates are described or redescribed. The first, Pontosaurus ribaguster is described from a relatively complete specimen discovered on Hvar Island, Croatia. Preservation of identifiable nektonic teleosts within the gastric cavity (the first identifiable...
The Evolutionary Ecology of Parasitic Strategies: Experimental Evolution with a Facultatively Ectoparasitic MiteDownload
Although parasitism is a ubiquitous lifestyle, little empirical evidence exists for how and why parasitism evolves from free-living lineages. Analysis of phylogenetic relationships among taxa that exhibit a range of lifestyles has aided in the development of a commonly proposed hypothesis for the...
Dromaeosaurids were small to medium sized theropod dinosaurs that diversified during the Late Cretaceous, reaching a near cosmopolitan distribution. They were diverse in morphology from the small four-winged gliders of Microraptorinae, to the bear-sized giant ‘raptors’ like Achillobator or...
Respiration, Acid/Base, Ammonia and Ionoregulatory Strategies in the Pacific hagfish (Eptatretus stoutii)Download
Hagfish feed on putrefied carrion, which poses several environmental challenges to the scavenger including hypoxia (Low PO2), hypercapnia (high PCO2) and high environmental ammonia (HEA). To any other organism, these conditions would be physiologically challenging; however, hagfish seem to have...
The ER mitochondria-associated membrane (MAM) is a hub for many calcium-mediated processes required for cell survival, including apoptosis, autophagy, and ATP production. In this thesis, we identified and characterized the interaction between MAM-enriched Rab32 and its effector Drp1, a master...
Epithelia form protective barriers and regulate molecule transport between the mesenchyme and environment. Amongst all metazoans, only sponges are said to lack 'true' epithelia however the physiology of sponge cell layers are rarely studied empirically. Aggregates and gemmules of a freshwater...
Leafrollers moths are one of the most ecologically and economically important groups of herbivorous insects. These Lepidoptera are an ideal model for exploring the drivers that modulate the processes of diversification over time. This thesis analyzes the evolution of Choristoneura Lederer, a well...