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Skip to Search Results- 16Electrophysiology
- 7Caffeine
- 2Anesthesia
- 2Calcium Imaging
- 2Genetics
- 12-p-(2-carboxyethyl)-phenethylamino-5′-N-ethylcarboxamidoadenosine-hydrochloride
- 1Abu-Sa'da, Omar SD
- 1Alles, Sascha R
- 1Chen, Yishen
- 1Cordingley, Dean M.
- 1Dimopoulos, Ioannis
- 1Gawad Gad,Sandra Sabry
- 5Centre for Neuroscience
- 4Department of Physiology
- 3Department of Pharmacology
- 2Medical Sciences-Medical Genetics
- 2Neuroscience
- 1Department of Biological Sciences
- 2Tse, Amy (Centre for Neuroscience and Department of Pharmacology)
- 1Ballanyi, Klaus (Physiology Department, University of Alberta)
- 1Ballanyi, Klaus (Physiology)
- 1Campbell, Shelagh (Biological Sciences)
- 1Chen, Xing-Zhen (Physiology)
- 1Cheung, Po-Yin (Department of Paediatrics), Co-Supervisor
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The Effect of Caffeine on the Neurobehavioral and Neuropathological Outcome of the Newborn Rat
DownloadSpring 2010
Caffeine is used for the treatment of apnea of prematurity. The objective of this study was to determine the long term neuropathological and neurobehavioral effects of caffeine on the immature rat brain. Newborn rats were injected with either caffeine, or normal saline from postnatal days 3 to 7,...
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Spring 2015
Besides being the most popular drug in the world, caffeine is an attractive tool used in research to help us answer fascinating scientific questions, because caffeine impinges on a number of molecular pathways. In my research, I used caffeine to study DNA repair pathways and insect xenobiotic...
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Fall 2013
Glomus cells of the carotid body are peripheral chemoreceptors that detect changes in arterial oxygen levels. Hypoxia suppresses oxygen-sensitive K+ channels in glomus cells, resulting in cytosolic Ca2+ ([Ca2+]i) elevation in glomus cells via the activation of voltage-gated Ca2+ channels. The...
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Influence of lipids (arachidonic acid and cholesterol) on calcium signalling in rodent pancreatic beta cells
DownloadFall 2010
Ca2+ is an important mediator of stimulus-secretion coupling in beta cells of the pancreatic islets, which secrete insulin in response to elevation in plasma glucose concentration. I studied the actions of two lipids, arachidonic acid (AA) and cholesterol, on enzymatically-dissociated single...
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Drosophila Mage, a component of Smc5/6 DNA response complex, confers resistance to caffeine and genotoxic stress and plays a role in the cell cycle and cell survival
DownloadFall 2014
Over 50 Melanoma-associated antigen (MAGE) genes have been identified in the human genome. They share a conserved 200 amino acid MAGE-homology domain (MHD). In yeast, the only MAGE homolog (Nse3) is a component of the Smc5/6 DNA damage response complex. In humans, MAGE proteins influence cell...
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Can caffeine alter blood potassium concentration or the perception of pain and fatigue after a 1 km cycling sprint?
DownloadSpring 2013
Caffeine is used by some athletes to improve endurance performance, however, the mechanism(s) by which caffeine elicits performance improvements have been unclear. The purpose of this study was to investigate the effects of caffeine on pain perception, fatigue perception, plasma catecholamine...
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Fall 2022
The reason and functional relevance of why we sleep continues to perplex researchers. One fundamental reason behind why sleep remains a mystery is because it is challenging to study given how easily it is disrupted. Anesthesia has been suggested to be a model for studying sleep given the...
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The effect of long-term interleukin-1 beta exposure on sensory neuron electrical membrane properties: implications for neuropathic pain
DownloadSpring 2011
The effect of interleukin-1 beta (IL-1β) on the electrical properties of sensory neurons was assessed at comparable levels and exposure times to those found in animal models of neuropathic pain. Experiments involved whole cell current- or voltage-clamp recordings from rat dorsal root ganglion...
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Fall 2014
An individual’s body weight is tightly regulated by balancing food intake with energy expenditure. This is accomplished in part by secretion of the hormone leptin by adipocytes, an excess of which signals to reduce appetite and increase activity through action in the hypothalamic region of the...
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Antagonistic modulation of spontaneous neural network activities in isolated newborn rat brainstem preparations by opioids and methylxanthines
DownloadFall 2012
Apnea of prematurity is a common problem among the infants born before term pregnancy. Administration of respiratory stimulating drugs methylxanthines is the most frequent therapy, often in combination with the use of intubation. Opioids are used to reduce the pain associated with intubation,...