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- 16Graduate and Postdoctoral Studies (GPS), Faculty of
- 16Graduate and Postdoctoral Studies (GPS), Faculty of /Theses and Dissertations
- 1Medicine and Dentistry, Faculty of
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Tracer Development for the Molecular Imaging of Breast Cancer: Synthesis and Biological Evaluation of C-3 Modified 2,5-Anhydro-D-mannitol Derivatives as Potential Tracer Molecules
DownloadSpring 2016
Mammography is the most frequently used imaging method for the detection of breast cancer. Despite the key role of mammography in the breast cancer detection, false-negative diagnosis by mammograms ranges from 4 to 34%. Positron emission tomography (PET), a tracer based molecular imaging method...
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Fall 2013
Thrombotic microangiopathies are group of diseases that refer to clinical and pathological syndromes where endothelial injury results in the manifestations of capillary thrombosis, microangiopathic hemolytic anemia, schistocytosis, and can lead to renal failure. In this thesis we aimed to study...
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Radiosynthesis and Optimization of 18F-Fluorinated GW2580 Derivatives as A Dual Trk/CSF-1R Radiotracer for Potential Use in PET Imaging
DownloadFall 2018
As one of the medical imaging modalities applied in clinical diagnosis of various diseases, positron emission tomography (PET) is used to non-invasively visualize cellular and molecular changes that are occurring in the human body. Fluorine-18 [18F] is the most widely used radionuclide for...
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2012
Radziwon-Balicka, A., Jurasz, P., Moncada de la Rosa, C.
Platelets, in addition to maintaining hemostasis, also stimulate angiogenesis by generating and releasing, upon activation, factors that promote the growth of new blood vessels. To date, at least 20 angiogenesis-regulating factors have been identified in platelets, including both promoters and...
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Plasma Membrane Organization and Endocytosis of CD36 in Human Microvascular Endothelial Cells
DownloadSpring 2016
The plasma membrane is a dynamic lipid bilayer that surrounds the cell, embedded with different plasma membrane proteins, aiding communication between the inside and outside of the cells. Its functions are achieved through an intricate organization of lipid-lipid, lipid-protein and...
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Novel Insights into the Role of O6-Methylguanine-DNA Methyltransferase in Glioblastoma Angiogenesis, Invasion, and Proliferation
DownloadFall 2012
Glioblastoma multiforme (GBM) is characterized by aberrant angiogenesis, rapid proliferation, and widespread invasion through the brain parenchyma. Thus, the prognosis for these tumors remains extremely poor despite aggressive multimodal treatment including chemotherapy with the alkylating agent...
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Molecular imaging of cyclooxygenase-2 (COX-2) and autotaxin (ATX) in cancer using positron emission tomography (PET)
DownloadFall 2020
Positron emission tomography (PET) relies on the use of β+-emitting radionuclide-bearing molecules congregating and decaying at a specific site of interest. Use of these molecules, called radiotracers, which target common tumor characteristics has become a pillar in the diagnosis of cancer and...
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Fall 2013
The placenta is an essential transitory fetal organ responsible for the key processes of nutrient, oxygen, and waste transfer between the mother and the fetus throughout gestation. Placental size is, importantly, known to correlate to fetal weight, and the malfunction and malformation of the...