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Versatile Polymer-Based Nanomedicines for Drug/Gene Delivery and Cell-based Therapy Applications
DownloadSpring 2021
Advances in polymer science and nanotechnology have allowed the development of biomaterials for cell-based applications, such as the delivery of a variety of drugs and genes, as well as supporting technologies, such as stem cell therapies, tissue engineering and cryopreservation. The progress in...
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2017-01-01
Gao, Yongfeng, Wei, Menglian, Li, Xue, Xu, Wenwen, Ahiabu, Andrews, Perdiz, Juliana, Liu, Zining, Serpe, Michael J.
Stimuli-responsive polymers are capable of changing their chemical and/or physical properties in response to environmental stimuli. This unique feature has allowed stimuli-responsive polymers to be used in a variety of applications. In this review, we present a basic introduction to the theories...
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2017-01-01
Zhang, Qiang, Colazo, Juan, Berg, Darren, Mugo, Samuel M., Serpe, Michael J.
Nanogels with a biomolecular coating (biocoating) were shown to be capable of triggered delivery of anticancer drug Doxorubicin. The biocoating was formed utilizing binding between glycogen and the tetra-functional lectin Concanavalin A, which can be triggered to disassemble (and release) upon...
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Spring 2016
Neurotrophic factor peptide analogues are capable of promoting healing by neurogenesis, enhancing neuronal survival and attenuating glial activation. In vivo peptide delivery is difficult due to susceptibility to proteases, but they are considered ideal therapeutics due to specificity, potency,...
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Design of Macromolecular Anti-cancer Drug Delivery Systems using Molecular Dynamics Simulation
DownloadFall 2015
In recent years, the application of self-associating block copolymer based drug delivery systems has attracted increasing attention as nano-sized carriers for the encapsulation and the controlled delivery of water insoluble drugs. Most of the drug formulations are based on the “trial and error”...