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- 1 Li, Jun
- 1Abeysundara, Namal W
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- 17Graduate Studies and Research, Faculty of
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- 4Biological Sciences, Department of/Journal Articles (Biological Sciences)
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- 1Roy Berg Kinsella Research Ranch/Journal Articles (Kinsella Ranch)
Cells require the ability to modulate function in response to their surroundings so that they are able to contribute to the survival of the organism. A key mechanism that allows tunable responses to changes in environment is by differential control of gene expression by transcriptional...
Fragile X Syndrome (FXS) is the most common genetic cause of Intellectual Disability, affecting 1 in 4000 boys and 1 in 6000 girls. Work in our lab using Drosophila melanogaster and since replicated in the mouse model has shown that excess protein synthesis is a major mechanism connecting the...
Vertebrate development requires the activity of multiple members of the myocyte enhancer factor 2 (mef2) gene family for muscle cell specification and subsequent differentiation. Additionally, it is thought that several muscle-specific functions of MEF2 family proteins require binding additional...
Hereditary Spastic Paraplegia (HSP) denotes a heterogeneous group of heritable neurodegenerative disorders predominantly characterized by progressive weakness and spasticity of the legs. Mutations in the gene SPAST are by far the most common, while mutations in the gene ATL1 are the second most...
The innate immune system is an evolutionarily conserved first line of defense against invasive microbes. Studies in the fruit fly, Drosophila melanogaster, revolutionized the field of immunology and cemented Drosophila as a premier model of innate immune defenses. The Drosophila immune deficiency...
Proliferative Signals Regulate Hemocyte Development and Intestinal Immunity in Drosophila melanogaster.Download
The innate immune system is an ancient line of resistance against intrusive microbial threats. This system integrates cellular, humoral, and barrier defenses to generate a protective immune response. These divisions are indispensable and conserved between Drosophila and mammals. Hemocytes are the...
Organelles serve to compartmentalize biochemical functions within the eukaryotic cell. However, to collectively maintain cellular homeostasis, organelles must communicate in some way in order to coordinate these functions. Two such organelles,the peroxisome and the lipid droplet, are both...
Samudrala, Ram , Zheng, Hongkun , Li, Jun, Yang, Shuang , Zhang, Jianguo , Yu, Haijing , McDermott, Jason , Wang, Wen , Yang, Huanming , Jiang, Huifeng , Yang, Lei , Wang, Jian , Wong, Gane K., Kristiansen, Karsten , Su, Jianning , Yu, Jun
If all cells in a multicellular organism contain exactly the same genetic information, the question arises of how tissue types with distinct gene expression profiles are formed and maintained over the life of the organism. These different temporal and spatial gene expression patterns are thought...
Retroposition is widely found to play essential roles in origination of new mammalian and other animal genes. However, the scarcity of retrogenes in plants has led to the assumption that plant genomes rarely evolve new gene duplicates by retroposition, despite abundant retrotransposons in plants...