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Skip to Search Results- 9Graduate and Postdoctoral Studies (GPS), Faculty of
- 9Graduate and Postdoctoral Studies (GPS), Faculty of /Theses and Dissertations
- 6Biological Sciences, Department of
- 6Biological Sciences, Department of/Journal Articles (Biological Sciences)
- 2Agricultural, Food and Nutritional Science, Department of
- 2Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
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Fall 2022
Biofouling is a serious problem in the medical, marine, and several other industrial fields as it poses significant health risks and financial losses. Therefore, there is a great need to endow surfaces with antifouling and antimicrobial properties to mitigate biofouling. For long-term biofouling...
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The pulmonary vasculature during exercise in health and mild chronic obstructive pulmonary disease
DownloadFall 2017
The purpose of this dissertation was to characterize the response of the pulmonary vasculature to exercise in health (including a pharmacological intervention) and in individuals with mild chronic obstructive lung disease. The first project studied the effect of a dopamine receptor blockade on...
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The Effect of Dopamine on Pulmonary Diffusing Capacity and Capillary Blood Volume Responses to Exercise
DownloadFall 2017
Pulmonary diffusing capacity increases during exercise to meet the increasing oxygen (O2) demand of the body. Expansion of pulmonary capillary blood volume (Vc) and diffusing membrane capacity (Dm) are important contributors to the increased diffusing capacity observed during upright cycle...
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Characterizing the Mesolimbic Dopamine Reward Pathway in a Magel2-null Mouse, a Model of Prader-Willi Syndrome
DownloadFall 2016
Prader-Willi Syndrome (PWS) is a genetic disorder characterized by extreme hyperphagia that can lead to severe obesity. The abnormal motivation to eat in PWS suggests a disruption in the hedonic feeding pathway, which is feeding based on reward as opposed to physiological need. Hedonic feeding is...
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Characterization of the Type VI Secretion System in the Bacterial Pathogen Acinetobacter baumannii
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Antibiotic resistant bacteria that cause hospital-acquired infections are a mounting concern for healthcare systems globally. Multidrug resistant (MDR) Acinetobacter baumannii has emerged as a common cause of nosocomial infections, and some isolates are now pandrug resistant. These infections can...
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Oxidative stress mediates estrogen receptor independent killing and contributes to tamoxifen resistance
Download2016
Godbout, Roseline, Brindley, David N., McMullen, Todd, Mackey, John R., Benesch, Matthew, Mi, Si, Venkatraman, Ganesh, Liu, Rong-Zong, Curtis, Jonathan M., Tang, Xiaoyun, Bekele, Raie T.
Tamoxifen is the accepted therapy for patients with estrogen receptor-α (ERα)-positive breast cancer. However, clinical resistance to tamoxifen, as demonstrated by recurrence or progression on therapy, is frequent and precedes death from metastases. To improve breast cancer treatment it is vital...
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Designed zinc finger proteins as novel therapeutics inhibiting the transcription of hepatitis B and duck hepatitis B viruses
DownloadFall 2010
The Hepatitis B virus (HBV) chronically infects 350 million individuals worldwide, leading to mortality by end-stage liver disease, liver cirrhosis, and hepatocellular carcinoma. The vaccine to prevent HBV infection is highly effective but is not extensively available in endemic areas, resulting...
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Cuticular plasticization in the tick, Amblyomma hebraeum (Acari: Ixodidae): possible roles of monoamines and cuticular pH
Download2010
Reynolds, S. E., Flynn, P. C., Kaufman, W. R.
Abstract: The degree of plasticization of the alloscutal cuticle of a 'hard' (ixodid) tick, Amblyomma hebraeum, and a 'soft' (argasid) tick, Ornithodoros moubata, was assessed throughout the blood-feeding period. Cuticle viscosity was calculated from rate of creep of cuticle under constant load...
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Structural and functional analysis of transmembrane XI of the NHE1 isoform of the na+/H+ exchanger
Download2009-01-01
Lee, Brian L., Li, Xiuju J., Liu, Yongsheng, Sykes, Brian D., Fliegel, Larry
The Na+/H+ exchanger isoform 1 is a ubiquitously expressed integral membrane protein that regulates intracellular pH in mammals by extruding an intracellular H+ in exchange for one extracellular Na+. We characterized structural and functional aspects of the critical transmembrane (TM) segment XI...
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Fall 2009
The computational ability of principal neurons and interneurons in the brain and their ability to work together in concert are thought to underlie higher order cognitive processes such as learning, memory, and attention. Dendrites play a very important role in neuronal information processing...