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Skip to Search Results- 6Dairy cattle
- 5Genome-wide association study
- 5Genomic prediction
- 2Epistasis
- 2Feed efficiency
- 2Heritability
- 2Dekkers, Jack C. M.
- 2Plastow, Graham S.
- 1Bao, Hua
- 1Basarab, J. A.
- 1Bishop, Stephen C.
- 1Carreira Bruinjé, Tony
- 1Ambrose, Divakar J (Department of Agricultural, Food and Nutritional Science)
- 1Coltman, David (Biological Sciences)
- 1Damaraju, Sambasivarao (Laboratory Medicine and Pathology)
- 1Davis, Corey (Biological Sciences)
- 1Dr. Changxi Li (Agricultural, Food & Nutritional Science)
- 1Lai, Raymond (Laboratory Medicine and Pathology)
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Fall 2023
The calving transition is a challenging period for dairy cows characterized by negative energy balance, metabolic dysfunction, and inflammation, each of which may compromise milk production. Despite extensive research in this area, much is still unknown on how to best manage this period. The...
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Identification of functional genes for feed efficiency traits via transcriptome analyses to enhance the genomic prediction accuracy in beef cattle
DownloadFall 2019
Residual feed intake (RFI), a measure of feed efficiency, and its component traits including average daily gain (ADG), dry matter intake (DMI) and metabolic weight (MWT) are traits of great economic importance to the beef industry. The genetic improvement of these traits can improve the...
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Looking beyond the standard genome-wide association study: Biologically-motivated methodological approaches to discover novel genetic variants associated with complex human traits and disease
DownloadFall 2018
The standard approach for testing associations between common single nucleotide genetic variants (referred to as single nucleotide polymorphisms or SNPs) and disease entails testing disease associations for each SNP in the genome individually. This “hypothesis-free” approach has identified...
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Improving Accuracy of Genomic Prediction for Economically Important Traits in Canadian Holstein Dairy Cattle
DownloadSpring 2017
Milk is a valuable source of energy, high quality protein, and several key minerals and vitamins for humans. Selection for milk production in dairy cattle was first based on phenotype and pedigree information and the knowledge of genetic parameters for the trait of interest. However, substantial...
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Genetic architecture of gene expression underlying variation in host response to porcine reproductive and respiratory syndrome virus infection
Download2017-04-10
Kommadath, Arun, Bao, Hua, Choi, Igseo, Reecy, James M., Koltes, James E., Fritz-Waters, Elyn, Eisley, Chris J., Grant, Jason R., Rowland, Robert R. R., Tuggle, Christopher K., Dekkers, Jack C. M., Lunney, Joan K., Guan, Le Luo, Stothard, Paul, Plastow, Graham S.
It has been shown that inter-individual variation in host response to porcine reproductive and respiratory syndrome (PRRS) has a heritable component, yet little is known about the underlying genetic architecture of gene expression in response to PRRS virus (PRRSV) infection. Here, we integrated...
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USING IN-LINE MILK PROGESTERONE DATA TO DETERMINE OVARIAN ACTIVITY PARAMETERS ASSOCIATED WITH REDUCED FERTILITY IN CANADIAN HOLSTEIN COWS
DownloadFall 2017
Improvements in genetic selection and dairy management practices have resulted in dramatic increases in individual milk production over past decades. However, this positive trend has been accompanied by decreased reproductive performance and fertility in dairy cows. Infertility in modern dairy...
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Fall 2017
In this dissertation, I focus on the study of genotype imputation in population data. Genotype imputation is a process of inferring missing values for genotype data and has been extended to predicting “untyped” genotypes for samples in low-density chips with a reference population assayed using...
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Genetic and genomic basis of antibody response to porcine reproductive and respiratory syndrome (PRRS) in gilts and sows
Download2016-01-01
Serao, Nick V. L., Kemp, Robert A., Mote, Benny E., Willson, Philip, Harding, John C. S., Bishop, Stephen C., Plastow, Graham S., Dekkers, Jack C. M.
Background:Our recent research showed that antibody response to porcine reproductive and respiratory syn-drome (PRRS), measured as sample-to-positive (S/P) ratio, is highly heritable and has a high genetic correlation with reproductive performance during a PRRS outbreak. Two major quantitative...
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Spring 2016
Polar bears (Ursus maritimus) were among the first large mammals to be assessed for genetic variation in the wild, and they remain a common subject of genetics studies. Although recent advances in genotyping technology have allowed for more accurate determination of population structure and the...
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2014
Sargolzaei, M., Li, C., Schenkel, F., Chen, L.
Background Genomic prediction in multiple populations can be viewed as a multi-task learning problem where tasks are to derive prediction equations for each population and multi-task learning property can be improved by sharing information across populations. The goal of this study was to...