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Skip to Search Results- 5Keeling, Christopher I.
- 4Bohlmann, Joerg
- 2Bohlmann, Jörg
- 2Breuil, Colette
- 2Chan, Simon K.
- 2Chiu, Christine C.
- 11Graduate and Postdoctoral Studies (GPS), Faculty of
- 11Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 8The NSERC TRIA Network (TRIA-Net)
- 8The NSERC TRIA Network (TRIA-Net)/Journal Articles (TRIA-Net)
- 6Biological Sciences, Department of
- 6Biological Sciences, Department of/Journal Articles (Biological Sciences)
- 3El-Kadi, Ayman (Faculty of Pharmacy and Pharmaceutical Sciences)
- 2Muehlenbachs, Karlis (Earth and Atmospheric Sciences)
- 1Ayman, El-Kadi (Pharmacy and Pharmaceutical Sciences)
- 1Brocks, Dion (Pharmacy and Pharmaceutical Sciences)
- 1El-Kadi, Ayman (Faculty of pharmacy and pharmaceutical sciences)
- 1El-Kadi, Ayman (Pharmacy and Pharmaceutical Sciences)
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Short- and long-term cold storage of jack pine bolts is associated with higher concentrations of monoterpenes and nutrients
Download2019-01-01
Guevara-Rozo, Sydne, Classens, Gail, Hussain, Altaf, Erbilgin, Nadir
Studies with conifer-infesting bark beetles commonly use bolts cut from trees to evaluate the effects of host tree quality on various aspects of insect biology. Yet, whether host quality changes between live trees and bolts cut from these trees has not been assessed. Particularly, changes in...
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Stable isotopic fingerprint of resins and ambers: validation of a novel paleoclimatic indicator
DownloadSpring 2014
Hydrous and anhydrous thermal maturation experiments were conducted to assess the extent to which diagenetic alteration overprints the primary stable δD and δ13C isotopic composition of resins. Modern resins recorded an average post-metabolic D exchange <1.9%, compared to only <0.5% for...
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Stable isotopic fingerprint of resins and ambers: validation of a novel paleoclimatic indicator
DownloadSpring 2014
Hydrous and anhydrous thermal maturation experiments were conducted to assess the extent to which diagenetic alteration overprints the primary stable δD and δ13C isotopic composition of resins. Modern resins recorded an average post-metabolic D exchange <1.9%, compared to only <0.5% for...
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Synthesis and evaluation of an [18F]-labelled antisense oligonucleotide as an imaging probe to measure cellular response to radiation therapy
DownloadFall 2010
Antisense oligodeoxynucleotides (asODNs) show strong binding and high selectivity and can be constructed to recognize specific cellular targets such as gene regulated mRNA. Radiolabelled asODNs have the potential to image gene expression through mRNA targeting and could be a valuable tool in the...
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The cytochrome P450 CYP6DE1 catalyzes the conversion of α-pinene into the mountain pine beetle aggregation pheromone trans-verbenol
Download2019-01-01
Chiu, Christine C., Keeling, Christopher I., Bohlmann, Joerg
The recent outbreak of the mountain pine beetle (Dendroctonus ponderosae; MPB) has afected over 20M hectares of pine forests in western North America. During the colonization of host trees, female MPB release the aggregation pheromone (−)-trans-verbenol. (−)-trans-Verbenol is thought to...
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The role of cytochrome P450 and the protective effect of EETs against isoproterenol-induced cellular hypertrophy in rat H9c2 cell line
DownloadSpring 2013
Cytochrome P450 (CYP) enzymes have been identified in the heart and their levels have been reported to be altered during cardiac hypertrophy and heart failure. Furthermore, CYP enzymes have been shown to metabolize arachidonic acid to cardioprotective epoxyeicosatrienoic acids (EETs) and...
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THE ROLE OF CYTOCHROME P450 AND THEIR ASSOCIATED ARACHIDONIC ACID METABOLITES IN THE INITIATION AND PROGRESSION OF CARDIAC HYPERTROPHY
DownloadSpring 2016
Heart failure (HF) is the leading cause of mortality and disability in adults worldwide. Cardiac hypertrophy is an independent risk factor and one of the major hallmarks of HF. Research in cardiac hypertrophy is considered as a research into the early events in the development of HF. The...
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The role of cytochrome P450 derived arachidonic acid metabolites against Angiotensin II-induced cardiac hypertrophy in Sprague Dawley rats and the RL-14 cell line
DownloadFall 2015
Several cytochrome P450 (CYP) enzymes and their arachidonic acid (AA) metabolites play essential roles in the maintenance of cardiovascular health, and their alteration gives rise to a number of cardiovascular diseases, including cardiac hypertrophy and heart failure. Recent data demonstrated...
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The Role of Subterminal Hydroxyeicosatetraenoic Acids in the Pathogenesis of Cardiac Hypertrophy
DownloadFall 2021
Cardiac hypertrophy is a complex condition which is characterized by increased mass of the heart muscle. If untreated, cardiac hypertrophy can ultimately lead to heart failure (HF), arrhythmia and sudden death. Accumulating evidence suggest that pathological cardiac hypertrophy is strongly...
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Transcriptome resources and functional characterization of monoterpene synthases for two host species of the mountain pine beetle, lodgepole pine (Pinus contorta) and jack pine (Pinus banksiana)
Download2013-01-01
Hall, Dawn E., Arango-Velez, Adriana, Dullat, Harpreet K., Keeling, Christopher I., Breuil, Colette, Liao, Nancy Y., Henderson, Hannah, Bohlmann, Jörg, Cooke, Janice E. K., Quesada, Alfonso L., Jones, Steven J. M., Chan, Simon K., Jancsik, Sharon, Docking, Roderick T., Li, Maria, Yuen, Macaire M. S.
Background The mountain pine beetle (MPB, Dendroctonus ponderosae) epidemic has affected lodgepole pine (Pinus contorta) across an area of more than 18 million hectares of pine forests in western Canada, and is a threat to the boreal jack pine (Pinus banksiana) forest. Defence of pines against...