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- 1Gibeault, Rebecca L
- 1Lacasse, Jonathan J
- 1Lapetina, Diego Lomnitzer
- 1Minard, Laura
- 1Nami Mollalou, Babak
- 1Raghuram, Nikhil
Anti-Cancer Mechanism of Trastuzumab via Blocking Nuclear HER2 Function and Epigenetic Mechanism of ResistanceDownload
HER2 receptor tyrosine kinase (encoded by ERBB2 gene) is overexpressed in approximately 25% of all breast cancer tumors (known as HER2-positive breast cancers). Overexpression of HER2 causes overactivation of downstream receptor tyrosine kinase pathways including PI3K/Akt and MAPK pathways and is...
Herpes simplex virus 1 (HSV-1) is a nuclear-replicating, double-stranded (ds) DNA virus. HSV-1 genes are expressed in a coordinate manner. The tegument protein VP16 first activates expression of the five immediate-early (IE) genes. Two IE proteins, ICP4 and ICP0, then activate early (E) and...
The nucleus is the defining feature of eukaryotic cells and its major function is to house the cell’s genome and segregate it from the surrounding cytoplasm. The membranes encapsulating the nucleus constitute the nuclear envelope (NE). The interactions between the NE and chromatin facilitate the...
Poxviruses, such as vaccinia virus (VACV) and myxoma virus (MYXV), actively modulate various cellular structures and functions to ensure effective replication and transmission. In the contrary, cells use several restriction mechanisms to mitigate these viruses. This evolutionary relationship is...
Chromatin plays a pivotal role in regulating critical DNA dependent processes, such as transcription. Chromatin and associated epigenetic modifications form the molecular basis of differentiation and development and are misregulated in disease states, such as cancer. Histone H1 molecules are key...
Chromatin structure is important aspect of transcriptional regulation. Replication-coupled (RC) nucleosome assembly is the process of depositing newly synthesized H3-H4 onto nascent DNA behind the replication fork, mediated by the histone chaperones Asf1, CAF-1, and Rtt106. The experiments...
Asf1 is a conserved H3/H4 histone chaperone with multiple functions in chromatin modulation. Using budding yeast as a model, we identify new pathways of Asf1 function, and expand current knowledge regarding the known roles of Asf1. First, we uncover novel genetic interactions between ASF1 and...
Herpes Simplex Virus Type 1 (HSV-1) establishes latent infections in neurons in vivo and lytic infections in epithelial cells and fibroblasts. During latent infections, HSV-1 transcription is restricted and the genomes are not replicated. Latent HSV-1 genomes are chromatinized, such that...