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Skip to Search Results- 1Agrawal, Amogh
- 1Baluch, Aliyah
- 1Bergeron, Amber
- 1Brachmann, Cole Garrett
- 1Conway, Jennifer
- 1Jin, Chaochao
- 4Department of Medicine
- 2Department of Mathematical and Statistical Sciences
- 2Faculty of Nursing
- 2School of Public Health
- 1Department of Agricultural, Food, and Nutritional Science
- 1Department of Biological Sciences
- 2Wang, Hao (Mathematical and Statistical Sciences)
- 1Anderson, Colin (Medical Microbiology and Immunology)
- 1Campbell, Patricia (Lab Medicine and Pathology)
- 1Clandinin, M. Tom (Agricultural, Food, and Nutritional Sciences
- 1Colleen Norris (Faculty of Nursing)
- 1Deepali Kumar, MD (Transplant Infectious Diseases)
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Characteristics of alpine plants and soils along an elevational gradient, Northern Selkirk Mountains, British Columbia
DownloadSpring 2019
Rates of climate change are accelerated at higher elevations, a pattern termed elevation-dependent warming (EDW). Consequently, the impacts of climate change on community patterning and soil development may be particularly evident in alpine environments. Alpine ecotone boundaries, such as...
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Fall 2016
Background: NK cells are a key cellular component of antibody-mediated rejection (ABMR), but their role in ABMR has not been identified. We postulated that NK cells are stimulated through their CD16a antibody receptors by donor-specific anti-HLA antibodies in ABMR. There is currently no direct...
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Spring 2015
Background: Heart transplant is life-saving for children with end-stage congenital heart disease or acquired heart failure. Critical illness following transplantation can include acute kidney injury (AKI). There is little data on the epidemiology of, risk factors for, or impact on outcomes of...
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Proximal Impact of Transplant Tolerance-Promoting Antibody Therapies on Antigen-Specific T Cell Reactivity
DownloadFall 2013
The development of a transient, tolerance-promoting therapy is a critical goal in transplantation. Antibody-perturbation of T cell activation signals is considered a promising candidate. However, the mechanisms of such therapies remain vague. The lack of cohesive and systematic knowledge in the...
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Fall 2017
This thesis focuses on formulating and analyzing non linear models for microbial dynamics vis-a-vis human and environmental health. Firstly, we develop and investigate a stoichiometric organic matter decomposition model in a chemostat culture that incorporates the dynamics of grazers. This...
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Spring 2010
These two studies investigate the immune responses of lung and kidney transplant recipients to the influenza vaccine. The study involving kidney transplant recipients developed a novel flow cytometry assay to measure cell-mediated immunity in response to influenza vaccination. The activation of...
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Fall 2017
In recent years, narratives about various embellished and imaginary risks of vaccination have come under criticism because of their implications for the widespread acceptance of vaccines. Criticisms of these narratives often accompany assumptions that all mainstream health professionals accept,...
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Utility of Screening-Bead Assay in Testing for Formation of Donor-Specific Anti-HLA Antibodies and Antibody-Mediated Rejection in Renal Allografts Post-Transplant.
DownloadFall 2020
Background: Present-day immunosuppressive therapy in renal allograft recipients targets cell-mediated immunity and has significantly improved outcomes over the years. However, allograft failure rates still approach 50% towards 10 years post-transplantation. Antibody-mediated rejection (ABMR) is...
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Diabetes and Influenza-Attributable Illness: The Rationale for Targeted Influenza Vaccinations in Adults with Diabetes
DownloadFall 2012
While guidelines for seasonal influenza vaccinations single out working age (< 65) adults with diabetes, vaccination rates in this group remain below national targets. Historically, there has been limited evidence to support these guidelines. This dissertation comprises four studies investigating...
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Spring 2013
Immunogenicity of intramuscular influenza vaccine is suboptimal in organ transplant recipients although intradermal vaccine may be superior by targeting dermal dendritic cells to stimulate a response. 229 patients were randomized to IM or high-dose ID vaccine during the 2010-11 season. Pre- and...