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Meiosis in eukaryotes includes a developmentally programmed pre-meiotic G2 phase arrest before the onset of MI division mediated by inhibitory phosphorylation of Cdk1. There are two inhibitory kinases, Wee1 and Myt1. Myt1 mediated Cyclin B-Cdk1 regulation serves as a conserved mechanism for...
In the newly fertilized embryo, meiotic and mitotic spindles form consecutively within the same egg cytoplasm. The order of events during this transition is controlled, in part, via the regulation of the microtubule cytoskeleton. Herein, I show that mel-43 is part of a small paralogous gene...
Mapping and characterization of mel-43(sb41), a gene required for early embryonic viability in C. elegansDownload
A genetic screen for dominant, temperature-sensitive, maternal-effect embryonic lethal mutations identified mel-43(sb41), a gene required for early embryonic viability (Mitenko et al., 1997). Linkage mapping placed mel-43 within a small region on chromosome IV. Genetic analyses suggested that...