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Skip to Search Results- 2Veldhoen, Richard
- 1Abdualmjid,Reem J
- 1Abdurrahim, Amna E.
- 1Araya, Luam Ellen
- 1Baghdasarian, Argishti
- 1Banadyga, Logan Elliott
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Anthocyanins and Gingerols Exhibit Synergism in their Anticancer and Antioxidant Effects in Vitro
DownloadFall 2022
Anthocyanins and gingerols are naturally occurring phenolic compounds abundant in berries and ginger, respectively. They have been reported to induce antioxidant effects, inhibit the growth of different cancer cell lines, and stimulate apoptosis by modulating different cellular signal pathways....
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Spring 2021
While PrP is almost always found in the glycosylated state, there has been very little study attempting to explore the effects of the size of glycans, the composition of glycans, and the site of glycosylation on the stability of PrP. These effects can potentially play an important role in the...
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Transcriptomic analysis of zebrafish prion protein mutants supports conserved cross-species function of the cellular prion protein; and zebrafish as a model for cisplatin induced ototoxicity and transition metals as potential ligands for Tlr4ba and Tlr4bb
DownloadFall 2021
The work presented in this thesis is split between two projects. The first utilises prp1 and prp2 knockout zebrafish to investigate physiological functions of the cellular prion protein (PrPC). The second builds upon the use of zebrafish as a model for hearing loss to confirm a role of toll-like...
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Fall 2021
Caspases are a family of enzymes that regulate biological processes, such as inflammation and programmed cell death, through proteolysis. For example, in the intrinsic pathway of apoptosis, cell death signaling involves cytochrome c release from the mitochondria, which leads to the activation of...
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Fall 2019
Breast cancer is the leading cause of death among women worldwide. Fortunately, death rates have been declining since 1990, due to the increase in early detection, testing, and improved treatment. However, despite the advancement of targeted and hormone therapies for certain molecular sub-types...
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Investigation of BCL-2 interacting killer (BIK) as a breast cancer biomarker and its role in failed apoptosis
DownloadSpring 2019
Breast cancer is the number one cause of cancer-associated deaths in women worldwide. It can be broadly classified into estrogen receptor (ER) positive or -negative subtypes which form the basis of treatment. Despite the therapeutic advancements, more than half a million women annually succumb to...
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SLC4A11 in Blinding Endothelial Corneal Dystrophies: Characterization, Molecular Defect and Potential Therapeutic Strategy
DownloadFall 2019
Endothelial Corneal Dystrophies (ECD), genetic blinding diseases with a heterogeneous pathophysiology, are the leading cause of endothelial keratopathy (corneal transplants). Patients manifest symptoms, including corneal edema with increased corneal thickness and loss of corneal endothelial cells...
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Bacterial stimulation of lipid vesicle production in green microalga Dunaliella tertiolecta
DownloadFall 2019
Algae and bacteria form complex interactions through the exchange of bioactive molecules and nutrients. A wide range of phenotypes, and often their very survival, are influenced by these chemically mediated relationships, shaping the ecology and diversity of marine communities. Here we sought to...
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Spring 2019
A bacterial colony constitutes a complex microcosm which is equipped with a wide range of defensive adaptations that allow the colony to survive adverse environmental conditions and predation. The extreme resilience of bacteria in colonies has been a subject of continued research for nearly two...
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Electrocoalescence of Water Droplets in Oil Emulsions: Effect of Electric Fields, Surfactants, and Chemical Demulsifiers
DownloadSpring 2019
Stabilization of water-in-oil droplets during bitumen extraction and refining process poses a major challenge in the oil sands industry. These crude oil emulsions are stabilized by rigid films at water droplet-oil interfaces. The salty water remaining in oil causes equipment corrosion, catalyst...