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The role of ezetimibe and simvastatin in modulating intestinal cholesterol transport, chylomicron profile and chylomicron-remnant uptake by the arterial wall in a rodent model of the metabolic syndromeDownload
Intestinally derived chylomicron remnants (CM-r) may contribute to atherogenic dyslipidemia during the Metabolic Syndrome (Mets). However, the combined effects of ezetimibe (EZ) and simvastatin (SV) on post-prandial (PP) dyslipidemia during MetS remains unclear, nor is it known whether the...
Modifiable cardiovascular disease (CVD) risk factors, such as adiposity, are already associated with atherosclerotic progression in childhood. Less is known about whether physical activity (PA) is associated with progression of atherosclerosis in non-clinical samples of children. This...
Sex Differences in the Relationship between Childhood Trauma and Cardiovascular Disease Risk in AdulthoodDownload
Childhood trauma is a chronic stressor that has been linked to cardiovascular disease (CVD). Evidence also shows that females may have a heightened reactivity to interpersonal and chronic stress than males. The subjects for this study included 6881 members of Statistics Canada's National...
Ovarian endocrine function has a major impact on homeostatic mechanisms in the cardiovascular system in women. In particular, estrogens play an important role in the regulation of vascular function. Epidemiological and experimental evidence links increased risk for cardiovascular disease with...
Quantitative and Qualitative Content Analysis of Breast Cancer, Heart Disease, and Stroke Media Messages from Local Canadian MediaDownload
This study examined media coverage of breast cancer (N=145) and heart disease and stroke (N=39) news articles, videos, advertisements, and images in a local Canadian context through quantitative and thematic content analyses. Statistical analysis (Cramer’s V) revealed significant differences in...
Mental health and chronic medical conditions: schizophrenia, its treatment, risk of metabolic complications, and health care utilizationDownload
Objective - To assess the relationship between schizophrenia and cardiovascular disease by evaluating metabolic risk associated with treatment for schizophrenia, prevalence of cardiovascular risk factors (CV-RF) and disease (CV-D), and health care utilization in people with schizophrenia...
Innovative strategic Canadian research training from TomorrOw’s Research Cardiovascular Health Care Professionals (TORCH).Download
Cardiovascular research training is experiential, and \"skills\" are traditionally acquired through a master-apprentice paradigm. The complexity of contemporary clinical research requires a new model for research training. Facilitated through a Strategic Training Program Initiative, the Canadian...
McCarthy, G., Crichton, N.J., Linck, T., Seers, K., Titchen, A., Kitson, A., Edwards, R.T., Wallin, L., Hawkes, C., Estabrooks, C.A., Mockford, C., Cox, K., Harvey, G., Eldh, A.C., McCormack, B., Rycroft-Malone, G.
Background: Research evidence underpins best practice, but is not always used in healthcare. The Promoting Action on Research Implementation in Health Services (PARIHS) framework suggests that the nature of evidence, the context in which it is used, and whether those trying to use evidence are...
Effects of High-Intensity Aerobic Interval Training on Cardiovascular Disease Risk and Health-related Quality of Life in Testicular Cancer Survivors: The HIITTS TrialDownload
Background: Testicular cancer (TC) survivors (TCS) are an understudied, high-risk group susceptible to late-onset treatment-related cardiovascular disease (CVD), psychosocial, and health-related quality of life (HRQoL) deficits in the years following treatment. Importantly, despite having the...