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Skip to Search Results- 1Airo, Adriana M
- 1Azad, Abul
- 1Chen, Xueyi
- 1Fagan-Garcia, Katharine
- 1Farhan, Maikel AA
- 1Griffiths, Cameron
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Fall 2013
West Nile virus (WNV) is a neurotropic, blood-borne flavivirus that can cause serious neurological disease in humans and animals. While significant progress has been made in identifying virus-encoded pathogenic determinants, very little is known regarding how these viral proteins interact with...
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Distinct Roles of Class 1 PI3K Isoforms in the Regulation of Beta Cell Exocytosis and Insulin Secretion
DownloadFall 2014
Type 2 diabetes (T2D) is characterized by peripheral insulin resistance and an insufficiency of insulin secretion from the pancreatic beta cell. The incidence of T2D is rising worldwide at an alarming rate. An increase in population growth, increased prevalence of obesity, and an aging population...
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Fall 2010
Mast cells are immune cells important in innate immunity. Besides their role in asthma and allergies, mast cells are critical effector cells against various pathogens. Mast cells are established to be protective against bacterial infections, but little is known about their functions in viral...
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Fall 2020
Despite their small size and apparent simplicity, viruses are capable of causing mass casualties, political turmoil, and global economic shut down. Due to their minimal genome (~10–12 kb), arboviruses such as Zika (ZIKV), Dengue (DENV), and Mayaro (MAYV) depend on many host molecules for...
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Inhibition and enhancement of Respiratory Syncytial Virus replication by nucleoside analogues and bis(indole) compounds
DownloadSpring 2019
Respiratory syncytial virus (RSV) is an Orthopneumovirus that infects the epithelium of the airways. Severe RSV infection of the lower respiratory tract in infants is a leading cause of pediatric hospitalizations. RSV also causes substantial morbidity in immunocompromised and elderly populations....
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Fall 2016
Thrombotic microangiopathy (TMA) is a broad term for a range of diseases that usually manifest with rapid failure of the affected organ. Although different in etiology, these diseases share a common pattern of injury originating in the vascular endothelium. In turn, the injured vasculature...
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Spring 2016
Flaviviruses, such as West Nile virus (WNV), Powassan virus (POW), and Saint Louis encephalitis virus (SLEV), are significant pathogens capable of causing serious neurological disease in both humans and animals. Despite their relevance to human health, treatment and vaccines for these viruses...
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Fall 2022
Heart transplantation (HTx) is a life-saving intervention for patients with end-stage heart failure. Nonetheless, the development of Chronic Allograft Vasculopathy (CAV) limits the longevity of transplanted cardiac allografts and the survival of recipients. The pathogenesis of CAV begins with a...
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Spring 2014
The introduction of WNV into North America in 1999 was followed by rapid spread throughout the continent. Today, WNV is an endemic pathogen in the west, with thousands of cases of severe infection reported annually. In addition to traditional vaccine research, there is an urgent need to...