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- 31Graduate Studies and Research, Faculty of
- 31Graduate Studies and Research, Faculty of/Theses and Dissertations
- 4CANHelp Working Group
- 4CANHelp Working Group/Journal Articles (CANHelp Working Group)
- 2Agricultural, Food and Nutritional Science, Department of
- 2Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
Polycomb protein methyltransferase, Enhancer of Zeste 2 (Ezh2), is frequently overexpressed in human malignancy and is implicated in cancer cell proliferation and invasion. Recently, several other polycomb proteins have been implicated in modulating the response to DNA double strand breaks, and...
Challenges in conducting community-driven research created by differing ways of talking and thinking about science: a researcher’s perspective.Download
Increasingly, health scientists are becoming aware that research collaborations that include community partnerships can be an effective way to broaden the scope and enhance the impact of research aimed at improving public health. Such collaborations extend the reach of academic scientists by...
Disease manifestations of Helicobacter pylori infection in Arctic Canada: using epidemiology to address community concerns.Download
Objectives Helicobacter pylori infection, linked to gastric cancer, is responsible for a large worldwide disease burden. H pylori prevalence and gastric cancer rates are elevated among indigenous Arctic communities, but implementation of prevention strategies is hampered by insufficient...
Microtubules and Energy Metabolism: Targets for Standard, Combination, and Novel Therapeutic Interventions and Monitoring of CancerDownload
The challenge of understanding and treating cancer has proven to be exceedingly complex. At this juncture, understanding cancer from the perspective of a breakdown of a complex cooperative system using a biophysical analysis may aid in improved treatments and prevention of this disease. In any...
Development of Novel Polymeric Micellar DACHPt for Enhanced Platinum Based Chemotherapy in Colorectal CancerDownload
One of the major limitations of chemotherapy in cancer treatment is the side effects of anti-cancer drugs. This happens due to non-selective distribution of most standard chemotherapies, and their action on cancer and all normal dividing cells. The objective of this project is to develop a novel...
A Pan Canadian Practice Guideline for Screening, Assessment, and Management of Cancer-Related Fatigue in Adults (Version 2)Download
Howell, Doris, Keshavarz, Homa, Broadfield, Larry, Hack, Tom, Hamel, Marc, Harth, Tamara, Jones, Jennifer, McLeod, Deborah, Olson, Karin, Phan, Stephanie, Sawka, Annie, Swinton, Nelda, Ali, Muhammad U.
Background Cancer-related fatigue (CRF) is a prevalent problem in cancer and has a side effect of treatment that often worsens during cancer treatment and can persist as a long-term problem for many patients including those in palliative care and cancer survivor populations. Reported prevalence...
Adiposity and fat loss in cancer: Exploring the prognostic significance and underlying mechanisms of adipose alterations in cancerDownload
During cancer progression, many patients will experience some degree of wasting of both muscle and adipose tissue. However, little is-known about adipose tissue alterations after a cancer diagnosis. Therefore, this research was conducted to first understand the prognostic significance of adipose...
Quantitative Magnetic Resonance Imaging (qMRI) is occupying an increasingly prominent role in the study of the brain, by virtue of its sensitivity to physiological and anatomical changes. However, because qMRI techniques tend to suffer from long scan durations and/or post-processing times, as...
Preliminary validation of a computer-based approach to find new lead molecules targeting the oncogenic Forkhead box M1 transcription factorDownload
The upregulation of the forkhead box M1 (FOXM1) transcription factor is directly correlated with cancer initiation, invasion, and drug resistance. Because the overexpression of FOXM1 is considered an important factor in carcinogenesis, this protein could be a relevant drug target in cancer...
Survival Benefit of Chemotherapy in Oropharyngeal Cancer Patients Treated with Surgery and Post-Operative RadiationDownload
Oropharyngeal squamous cell carcinoma (OPSCC) is the third most common cancer of the head and neck. The incidence of all subtypes of head and neck squamous cell carcinoma has decreased over the past 30 years in Canada and most of the world except for OPSCC. The increasing incidence of OPSCC over...