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- 1Abdulsalam Alharbi
- 1Aktary, Zackie M
- 1Alshamsan, Aws
- 1Armanious, Hanan A R
- 1Beesley, Richelle Marie
- 1Binkhathlan, Ziyad
Survival Benefit of Chemotherapy in Oropharyngeal Cancer Patients Treated with Surgery and Post-Operative RadiationDownload
Oropharyngeal squamous cell carcinoma (OPSCC) is the third most common cancer of the head and neck. The incidence of all subtypes of head and neck squamous cell carcinoma has decreased over the past 30 years in Canada and most of the world except for OPSCC. The increasing incidence of OPSCC over...
Head and neck squamous cell carcinoma (HNSCC) is the 6th most prevalent cancer worldwide with rates of human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) dramatically increasing. The overexpression of enhancer of zeste homolog 2 (EZH2), a histone methyltransferase...
The analysis of wide-angle cellular light scattering patterns is a challenging problem. Small changes to the organization, orientation, shape, and optical properties of scatterers and scattering populations can significantly alter their complex two-dimensional scattering signatures. Because of...
Despite the research to date, the characteristics and impact of cognitive dysfunction (CD) in cancer patients following chemotherapy is still not well understood. It is estimated approximately 20% of patients will manifest measurable cognitive deficits on neuropsychological testing...
Application of ROC curve analysis to metabolomics data sets for the detection of cancer in a mouse modelDownload
The goal of this study was to show that quantifiable metabolic changes may be used to screen for cancer. NIH III nude mice (n=22) were injected with human GBM cells, with daily urine samples collected pre and post-injection. 14 mice were injected with saline to serve as controls. The...
There is substantial evidence of the elevated risk of cancer among individuals with type 2 diabetes. Very little is known, however, about the role that antidiabetic therapies play in this relationship. The objective of this program of research was to examine whether there is a therapeutic risk...
Comparison of tooth loss between intensity modulated and non-intensity modulated radiotherapy in head and neck cancer patientsDownload
Advanced radiotherapy (RT) systems (intensity modulated radiotherapy, IMRT) is widely used to treat head and neck cancer. A combination of radiation and chemotherapy potentially increases toxicity as well as dental complications. Tooth loss was retrospectively assessed using oral cavity,...
DNA is a detailed layout of instructions for cellular function. The integrity of human DNA is constantly challenged by a barrage of exogenous and endogenous sources. A regime of genome stability maintenance has evolved to repair the many different types of DNA damage. A form of communication...
Chemoresistance is one of the major hurdles to induce a cure in patients with epithelial ovarian cancer (EOC). RUNX3, belonging to the family of RUNX transcription factors, has been shown to act in an oncogenic manner by promoting proliferation and colony formation when overexpressed, in EOC....
Cancer is the leading cause of death from disease among adolescents in Canada. Although cancer is a well-researched disease process in the medical and nursing literature, adolescence is relatively understudied, with minimal evidence on strategies to promote healthy emotional adjustment...