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Skip to Search Results- 2Kinnaird, Adam
- 1Abdulsalam Alharbi
- 1Akhnokh, Maria Kodsy
- 1Aktary, Zackie M
- 1Alolayan, Waad Riyad
- 1Alshamsan, Aws
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Fall 2014
Infection with herpes simplex virus type 1 (HSV-1) leads to the rapid and complete loss of mitochondrial DNA (mtDNA) and mitochondrial messenger RNA (mt-mRNA), effectively eliminating gene expression within mitochondria. Previous work determined that a unique 3’ co-terminal transcript arising...
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Fall 2013
Plakoglobin (γ-catenin) is a member of the Armadillo family of proteins and a homolog of β-catenin with similar dual adhesive and signaling functions. The adhesive function of these proteins is mediated by their interactions with cadherins and their signaling function by association with various...
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Molecular imaging of cyclooxygenase-2 (COX-2) and autotaxin (ATX) in cancer using positron emission tomography (PET)
DownloadFall 2020
Positron emission tomography (PET) relies on the use of β+-emitting radionuclide-bearing molecules congregating and decaying at a specific site of interest. Use of these molecules, called radiotracers, which target common tumor characteristics has become a pillar in the diagnosis of cancer and...
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Muscle Abnormalities in cancer patients: Exploring the biological characteristics of skeletal muscle of cancer patients
DownloadFall 2019
Computed tomography-derived muscle measures of sarcopenia and low muscle radiodensity have been associated with poor outcomes in cancer patients, however, the biological characteristics of the muscle in this population are not well understood. This research was conducted to first evaluate muscle...
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Myeloperoxidase-mediated bio-activation of NSAIDs in leukemia cells: Potential selective cytotoxicity
DownloadFall 2019
Several lines of evidence have pointed to the potential benefit of anti-inflammatory drugs (NSAIDs) in cancer therapy due to the well-established correlation between cancer and chronic inflammation. Acute myeloid leukemia (AML) cells overexpress myeloperoxidase (MPO), which has been studied for...
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New Insight into the Role of Myocardial Fatty Acid Uptake and Utilization in Health and Disease
DownloadFall 2013
All mammalian cells rely on adenosine triphosphate (ATP) to maintain function and for survival. The heart has the highest basal ATP demand of any organ due to the necessity for continuous contraction. As such, the ability of the cardiomyocyte to monitor cellular energy status and adapt the supply...
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Nutritional Factors Impacting Intestinal Lipid Metabolism Using a Model of Low Birth Weight Swine
DownloadSpring 2018
Introduction: Non-communicable diseases (NCDs) such as obesity, type 2 diabetes (T2D) and cardiovascular disease (CVD) are increasing at an alarming rate globally. A common feature in these conditions is increased adiposity leading to insulin resistance (IR). Dyslipidemia is a major contributing...
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Fall 2010
Almost all mammalian cells contain energy-producing organelles called mitochondria. Phosphatidylethanolamine (PE) is a phospholipid which has been implicated to be important for mitochondrial function. The majority of mitochondrial PE is synthesized in mitochondria using the phosphatidylserine...
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Physical Therapy Interventions for Children and Adolescents with Cancer: Collating the Evidence from Research and Clinical Practice
DownloadSpring 2018
Purpose: Children and adolescents with cancer who undergo cancer treatment are at high risk of developing serious late and long-term physical effects, many of which may be amenable to physical therapy (PT). Little is known about the benefits of PT or the services currently provided to address...