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- 2Brain fatty acid-binding protein
- 1Anisotropic Diffusion
- 1Arachidonic acid
- 1BFABP
- 1Brain tumour
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Fall 2022
From the mechanical processes that produce the convolutions in the human brain needed for complex thought, to the precise and controlled movements derived by intuitive calculations of body position in figure skating, mechanics plays a role in everything we do. In this thesis, we apply and examine...
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Fall 2016
Gliomas, tumours arising from the glial cells of the nervous system, are some of the most difficult tumours to treat. In particular, glioblastoma are a particularly aggressive glioma subtype carrying a life expectancy of only 14 months. Typically, treatment combines surgery, radiation and...
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Combination Radiation Therapy and Oncolytic Vaccinia Virus Therapy in Preclinical Models of Glioma
DownloadSpring 2017
Gliomas are the most common primary malignant brain tumour in adults, with glioblastoma multiforme (GBM), the most common and most deadly form of glioma, making up over half of all diagnosed cancers in the brain/central nervous system. The standard of care for gliomas has remained unchanged for...
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Fall 2012
Malignant gliomas (MG) are the most common and aggressive brain cancers. FABP7 is an intracellular lipid trafficking molecule whose expression correlates with reduced MG patient survival. FABP7 has been shown to increase the migratory behaviour of MG cells. Moreover, the migratory behaviour of...
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Fall 2015
Malignant glioma (MG), comprised of grade III (anaplastic astrocytoma) and grade IV (glioblastoma) astrocytoma, is the most common adult brain tumour, with an incidence of ~4 in 100 000 people. Despite aggressive treatment with surgery, radiation, and chemotherapy, survival remains dismal, with...
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Fall 2010
Patients diagnosed with malignant glioma tumours have median survivals of 1.6 yrs and 5 months, respectively, highlighting the deadly nature of this disease. Despite aggressive multimodal treatment, patients with malignant glioma often present with secondary brain tumours at sites distal to the...