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- 3Wu, Jianping
- 2Chakrabarti, Subhadeep
- 2Davidge, Sandra T.
- 2Kaufman, Susan
- 2Morton, Jude S.
- 37Graduate and Postdoctoral Studies (GPS), Faculty of
- 37Graduate and Postdoctoral Studies (GPS), Faculty of /Theses and Dissertations
- 8Agricultural, Food and Nutritional Science, Department of
- 8Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
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- 1Renewable Resources, Department of/Journal Articles (Renewable Resources)
- 5Department of Agricultural, Food, and Nutritional Science
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- 2Kar, Satyabrata (Medicine and Psychiatry)
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- 1Carlos A Velázquez (Faculty of Pharmacy and Pharmaceutical Sciences)
- 1Davidge, Sandra (dept. of Physiology)
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Fall 2022
Contraction-mediated inhibition of sympathetic vasoconstriction (sympatholysis) is enhanced in female compared with male rats. Acute pharmacological blockade of nitric oxide (NO) production abolished the sex difference in sympatholysis, indicating that NO-mediated sympatholysis is elevated in...
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Glial Expression of Amyloid Precursor Protein (APP) and its Processing Enzymes in the ANPC Mouse Model
DownloadFall 2021
Alzheimer’s disease (AD) is a complex and progressive neurodegenerative disorder believed to be triggered by the accumulation of β-amyloid (Aβ) peptides derived from the proteolytic processing of amyloid precursor protein (APP). The regions primarily affected in AD brains are the hippocampus and...
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Insights into Membrane Type-1 Matrix Metalloproteinase cleavage of the Low-density Lipoprotein Receptor
DownloadSpring 2021
The Low-density lipoprotein receptor (LDLR) mediated cellular uptake of LDL is the main pathway for plasma LDL cholesterol (LDL-C) clearance. However, the LDLR can be proteolytically cleaved to release its soluble ectodomain (sLDLR) into the extracellular milieu and as such reducing its LDL-C...
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Investigating the Role of PCSK9 C-terminal Domain in the Regulation of Low-Density Lipoprotein Receptor and Cholesterol Metabolism
DownloadSpring 2020
Atherosclerotic cardiovascular disease (CVD) is the leading cause of death worldwide. Long-term elevated low-density lipoprotein cholesterol (LDL-C) levels are the major risk factors for the development of atherosclerotic lesions, which can eventually lead to myocardial infarction and many...
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Culture and Characterization of Kefir Organisms to Reproduce the Health Benefits of Traditional Kefir
DownloadSpring 2020
Fermented dairy products such as kefir have long been associated with a host of health benefits; however, the role that microbial composition has in these benefits has not been properly examined. This research aimed to examine how kefir impacts host metabolic health, as well as how alterations to...
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The Effect of Inhaled Nitric Oxide on Maximal Oxygen Consumption in High-fit and Untrained Individuals
DownloadFall 2019
Previous work suggests that endurance-trained athletes have superior pulmonary vasculature function as compared to untrained individuals, which may contribute to their greater maximal oxygen uptake (V̇O2max). Inhaled nitric oxide (iNO) improves pulmonary vascular compliance at rest in healthy...
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Traditional kefir reduces weight gain and improves plasma and liver lipid profiles more successfully than a commercial equivalent in a mouse model of obesity
Download2018-07-01
Bourrie, Benjamin C.T., Cotter, Paul D., Willing, Ben P.
Kefir, a fermented milk beverage, has shown promise in alleviating obesity and associated metabolic dysfunction. However, microbial characteristics are variable among traditional kefirs, and commercial kefirs drastically differ from traditional kefir. This study investigated the ability of four...
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Are Sex and Estrogen Modulators of Sympathetic Vascular Control in Resting and Contracting Skeletal Muscle?
DownloadSpring 2018
The purpose of this thesis was to investigate whether sex and estrogen modulate sympathetic neurovascular control in resting and contracting skeletal muscle. This thesis also investigated the hypothesis that the effects of sex and estrogen on neurovascular control would be mediated by the signal...
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Spring 2017
Pulses of ecdysone, a steroid hormone, play an integral role during insect development however, how these ecdysone pulses are regulated has been relatively unexplored. I have shown that the presence of nitric oxide (NO) within the larval prothoracic gland (PG), the principal source of larval...
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Impact of a 3-year multi-centre community-based intervention on risk factors for chronic disease and obesity among free-living adults: the Healthy Alberta Communities study
Download2016-01-01
Lytvyak, E., Olstad, D. L., Schopflocher, D. P., Plotnikoff, R. C., Storey, K. E., Nykiforuk, Candace I.J., Raine, K. D.
Background: Healthy Alberta Communities (HAC) was a 3-year community-based intervention to reduce lifestyle-related risk factors for chronic disease and obesity at a population-level. The current paper examines changes in blood pressure (BP) and anthropometric indicators within HAC communities...