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- 1Biopharmaceutical
- 1Biopharmaceutics
- 1Biphasic dissolution
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Novel Biopharmaceutical Development Investigations Towards Drug and Formulation Performance Optimization
DownloadFall 2021
For a drug to excerpt pharmacological action after oral intake, it first needs to be released from the formulation, get into solution (dissolve), be absorbed, and reach the systemic circulation. Since only solubilized drugs can be absorbed, and thus have therapeutic effect, the understanding of...
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The Dissolution Behavior of Ibuprofen and Griseofulvin in Bicarbonate Buffer Compared to Phosphate Buffer Using Intrinsic Dissolution Rate and Biphasic Dissolution
DownloadFall 2018
In the small intestine, bicarbonate is the main buffering system to adjust the pH after the gastric emptying to pH 5.5-6.8. Bicarbonate gathered some attention to be used as a dissolution media to better mimic the in-vivo environment. However, in vitro the evaporation of CO2(g) interferes with...