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Introduction: Asthma is a chronic inflammatory disease characterized by intermittent episodes of acute airway inflammation and bronchoconstriction. Although asthma is generally considered a disease of the airways, asthma is also associated with an increased risk of developing cardiovascular (CV)...
An Analysis of the Environmental Risk Factors of Childhood Asthma and Asthma-like Symptoms: Results from the National Longitudinal Survey of Children and YouthDownload
It is known that a multitude of environmental factors are implicated in the incidence of asthma and asthma symptoms among children; however, previous research has provided inconsistent and/or insufficient evidence as to whether residing in a farming environment during childhood can lead to a...
Outdoor Air Pollution and Children´s Asthma in the Census Metropolitan Area of Edmonton, Alberta: the Influence of Place of Residence and Socioeconomic PositionDownload
Background: Asthma is the most common chronic respiratory disease in children and air pollution has been implicated in its development and exacerbations worldwide. The Census Metropolitan Area of Edmonton (CMAE), Alberta, has unique air pollution sources (traffic and industrial related air...
Developing a Patient-Driven Arts-Based Knowledge Translation Tool for Parents of Children with AsthmaDownload
Background: Family-centered education is critical to managing childhood asthma, the most common chronic disease of childhood in North America. Parents are largely responsible for the day-to-day management of their child’s asthma; as such, finding effective ways to educate parents about asthma is...
Maternal Depressive Symptoms across Early Childhood and Asthma in School Children: Findings from a Longitudinal Australian Population Based StudyDownload
There is a growing body of evidence attesting to links between early life exposure to stress and childhood asthma. However, available evidence is largely based on small, genetically high risk samples. The aim of this study was to explore the associations between the course of maternal depressive...
Inconsistent results have been reported in studies investigating the relationship between serum vitamin D levels and respiratory outcomes. In this thesis, data from the Canadian Health Measures Survey were used to examine the relationship between serum 25-hydroxy vitamin D [25(OH)D] levels and...
Influenza pandemic occurs when a novel influenza virus subtype for which humans do not have sufficient immunity emerges and spreads quickly from person-to-person worldwide. Influenza pandemics result in serious consequences on human health and economy. In April 2009, the World Health Organization...
This thesis examines the pathophysiology of asthma, attempts to determine the cellular mechanisms behind viral-induced immune memory mediated asthma exacerbations, and investigates urinary metabolomic biomarkers of asthma and neonatal hypoxia.
Virus Induced Asthma Exacerbations: Immunologic Mechanisms and Metabolomic Biomarkers
Asthma is a complex multifaceted chronic inflammatory disease that is characterized clinically by reversible airflow obstruction, shortness of breath, coughing, and wheezing. Asthma is the most common chronic disease in children, and is differentiated into many phenotypes with multiple triggers....
Epidemiological studies correlate vitamin D deficiency with asthma severity. Calcitriol modulates receptor and cytokine expression from various leukocytes in an anti-inflammatory manner. Despite eosinophil activity during mucosal inflammation, knowledge on the direct effect of calcitriol on this...