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- 1Aghazadeh Habashi, Ali
- 1Alsaad,Abdulaziz M
- 1Beaulieu, Michael J.
- 1El-Sherbeni, Ahmed Abd El-Hakeem
- 1Elkhatali, Samya
- 1Wattar, Nour
- 1Brocks, Dion (Pharmacy and Pharmaceutical Sciences)
- 1Dr. Ayman El-Kadi
- 1El-Kadi, Ayman (Faculty of pharmacy and pharmaceutical sciences)
- 1El-Kadi, Ayman (Pharmacy and Pharmaceutical Sciences)
- 1Field, Catherine (Agricultural, Food and Nutritional Science)
- 1Jamali, Fakhreddin (Pharmaceutical Sciences)
The role of cytochrome P450 derived arachidonic acid metabolites against Angiotensin II-induced cardiac hypertrophy in Sprague Dawley rats and the RL-14 cell lineDownload
Several cytochrome P450 (CYP) enzymes and their arachidonic acid (AA) metabolites play essential roles in the maintenance of cardiovascular health, and their alteration gives rise to a number of cardiovascular diseases, including cardiac hypertrophy and heart failure. Recent data demonstrated...
Role of CYP-mediated Arachidonic Acid Metabolites in Development of Cardiac Hypertrophy and Chronic Doxorubicin-induced CardiotoxicityDownload
Drug-induced cardiotoxicity is classified as a predisposing factor leading to cardiac hypertrophy and heart failure. Of importance, doxorubicin (DOX, adriamycin) is considered as an effective anticancer agent whose major limiting side effect is cardiotoxicity. Of importance, several studies...
Malignant gliomas (MG) are the most common and aggressive brain cancers. FABP7 is an intracellular lipid trafficking molecule whose expression correlates with reduced MG patient survival. FABP7 has been shown to increase the migratory behaviour of MG cells. Moreover, the migratory behaviour of...
Maternal Essential Fatty Acid Status During Pregnancy and Postpartum in the Alberta Pregnancy Outcomes and Nutrition (APrON) Study and Infant OutcomesDownload
Docosahexaenoic (DHA) and arachidonic (AA) acids are essential fatty acids found in breast milk and are important for the infant’s brain development and cognitive functions such as those that regulate sleep and crying. The overall goal of this research was to use a large maternal infant cohort,...
MODULATING CYTOCHROME P450-MEDIATED ARACHIDONIC ACID METABOLISM AS A POTENTIAL NEW TREATMENT MODALITY FOR CARDIAC HYPERTROPHYDownload
Arachidonic acid (AA) metabolism has long been a very appealing target for drug discovery and development efforts. Beside cyclooxygenase and lipoxygenase pathways, AA is also metabolized by the recently recognized cytochrome P450 (P450) pathway, forming several biologically-active...
Influence of lipids (arachidonic acid and cholesterol) on calcium signalling in rodent pancreatic beta cellsDownload
Ca2+ is an important mediator of stimulus-secretion coupling in beta cells of the pancreatic islets, which secrete insulin in response to elevation in plasma glucose concentration. I studied the actions of two lipids, arachidonic acid (AA) and cholesterol, on enzymatically-dissociated single...
Glucosamine Anti-Inflammatory Dose-Effect Correlation and Its Influence on the Renin-Angiotensin System Components and Arachidonic Acid Metabolites under Inflammatory Condition in the Rat with Adjuvant ArthritisDownload
Crystalline glucosamine (GlcN) sulfate salt formulation is approved as a prescription drug with anti-inflammatory effects for the management of osteoarthritis (OA) in the European Union, while it is considered as a nutraceutical in North America. The effectiveness of GlcN for ameliorating the...