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The processing of amyloid precursor protein (APP) by β- and γ-secretases produces amyloid β (Aβ) peptide, the principal component of the neuritic plaques found in Alzheimer’s disease (AD) pathology. The enzyme γ-secretase is a multimeric protein consisting of presenilins-1/2 (PS1/PS2), nicastrin,...
Objectives: The purpose of this review is to critically evaluate the available evidence from the published scientific literature on dementia care and service provision in rural and remote settings from the perspective of formal/paid caregiving, in order to assess the current state of knowledge,...
This is the protocol for a review and there is no abstract. The objectives are as follows: 1.To evaluate the effects of physical activity programs on function (e.g., activities of daily [ADLs], physical function), cognition, mood, behaviour, and mortality in older persons with dementia. 2.To...
Incidence and prevalence of dementia in linked administrative health data in Saskatchewan, Canada: A retrospective cohort studyDownload
Kosteniuk, Julie G., Crossley, Margaret, Teare, Gary F., Stewart, Norma J., Quail, Jacqueline M., Kirk, Andrew, Bello-Haas, Vanina Dal, O’Connell, Megan E., Forbes, Dorothy A., Morgan, Debra G., Innes, Anthea
Background Determining the epidemiology of dementia among the population as a whole in specific jurisdictions – including the long-term care population–is essential to providing appropriate care. The objectives of this study were to use linked administrative databases in the province of...
The prevalence of dementia in older adults is increasing.Due to cuts in funding for formal support,many families are having to provide care for a loved one with dementia at home.This systematic review gathered and synthesized information on interventions designed to enhance the well-being of...
There is ample evidence that autophagy is affected in Alzheimer’s disease (AD) but the causes, the nature of the dysfunction and the mechanisms of autophagy impairment are unclear. Autophagy depends on vesicular trafficking and membrane fusion, events that rely on several protein complexes and...
Role of Glutamate and GABA in a mouse model expressing mutant human APP in the absence of NPC1 proteinDownload
Cholesterol plays a critical role in Alzheimer’s disease (AD) pathogenesis, but the underlying mechanisms remain unclear. To address this issue we have generated a line of ANPC transgenic mice that overexpress mutant-human amyloid precursor protein in the absence of cholesterol transporting...