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- 11Alzheimer's disease
- 1APP and Aβ metabolism
- 1Alzheimer's disease--Patients--Family relationships
- 1Alzheimer's disease--Patients--Institutional care
- 1Alzheimer's disease--Testing
- 1Cochrane, Karen
- 1Ghoshal, Bibaswan
- 1Hammermaster, Colleen
- 1Kodam, Anitha
- 1Maulik, Mahua
- 1O'Rourke, Hannah M
Roles of the Insulin-like Growth Factor-II/Cation-independent Mannose 6-phosphate Receptor and Cathepsin D in Alzheimer’s Disease PathologyDownload
Alzheimer’s disease (AD) is the most common type of senile dementia affecting the elderly. A critical contributing factor to the neurodegeneration and development of AD pathology stems from the processing of amyloid precursor protein (APP), leading to the generation of β-amyloid (Aβ) peptides....
Background: The prevalence of dementia, a progressive and incurable condition that affects memory and daily function, is increasing worldwide. The perspective of people with dementia can be captured to better understand which factors impact quality of life for this particular population. Such...
Use of autobiographical memory cues as cognitive support for episodic memory: Comparison of individuals with mild-stage Alzheimer's disease and healthy older adultsDownload
The purpose of the study was to examine the effectiveness of autobiographical memories to support the improvement of episodic memory (i.e., word recall) in patients with mild- stage Alzheimer’s Disease (AD) and healthy older adults. Participants included 20 healthy young-old adults (M Age =...
Alzheimer’s disease (AD) is a complex neurodegenerative disorder believed to be triggered by the accumulation of β-amyloid (Aβ)-related peptides derived from the proteolytic processing of amyloid precursor protein (APP). Research over the last two decades has shown that alterations in the levels...
The processing of amyloid precursor protein (APP) by β- and γ-secretases produces amyloid β (Aβ) peptide, the principal component of the neuritic plaques found in Alzheimer’s disease (AD) pathology. The enzyme γ-secretase is a multimeric protein consisting of presenilins-1/2 (PS1/PS2), nicastrin,...
Role of Glutamate and GABA in a mouse model expressing mutant human APP in the absence of NPC1 proteinDownload
Cholesterol plays a critical role in Alzheimer’s disease (AD) pathogenesis, but the underlying mechanisms remain unclear. To address this issue we have generated a line of ANPC transgenic mice that overexpress mutant-human amyloid precursor protein in the absence of cholesterol transporting...