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Skip to Search Results- 26Alzheimer's disease
- 4Dementia
- 3Amyloid precursor protein
- 3Cognitive impairment
- 3Interventions
- 3Meta-analysis
- 17Graduate and Postdoctoral Studies (GPS), Faculty of
- 17Graduate and Postdoctoral Studies (GPS), Faculty of /Theses and Dissertations
- 8Nursing, Faculty of
- 6Nursing, Faculty of/Chronicity
- 1University of Saskatchewan
- 1University of Saskatchewan/Journal Articles (Saskatchewan)
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2003
The prevalence of dementia in older adults is increasing.Due to cuts in funding for formal support,many families are having to provide care for a loved one with dementia at home.This systematic review gathered and synthesized information on interventions designed to enhance the well-being of...
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Spring 2016
There is ample evidence that autophagy is affected in Alzheimer’s disease (AD) but the causes, the nature of the dysfunction and the mechanisms of autophagy impairment are unclear. Autophagy depends on vesicular trafficking and membrane fusion, events that rely on several protein complexes and...
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Role of Glutamate and GABA in a mouse model expressing mutant human APP in the absence of NPC1 protein
DownloadSpring 2013
Cholesterol plays a critical role in Alzheimer’s disease (AD) pathogenesis, but the underlying mechanisms remain unclear. To address this issue we have generated a line of ANPC transgenic mice that overexpress mutant-human amyloid precursor protein in the absence of cholesterol transporting...
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Fall 2020
Tauopathies are a class of neurological disorders associated with the aggregation of the tau protein into neurofibrillary tangles. The most prominent tauopathy is Alzheimer’s disease (AD), which presents as two forms: early onset (familial, fAD) and late onset (sporadic, sAD). sAD does not have a...
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2011
Innes, Anthea, Morgan, Debra, Kosteniuk, Julie
Objectives: The purpose of this review is to critically evaluate the available evidence from the published scientific literature on dementia care and service provision in rural and remote settings from the perspective of formal/paid caregiving, in order to assess the current state of knowledge,...
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Gait and Cognition: Exploring Cognition and Dual-task Costs in a Group of Community Dwelling Alzheimer’s Disease Patients over 6 Months
DownloadFall 2022
Alzheimer’s disease is a progressive neurological disorder resulting in cognitive decline affecting many activities of daily living including gait. Many tools exist to monitor AD progression, including cognitive examinations, and functional tests of mobility. The purpose of the present study is...
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Incidence and prevalence of dementia in linked administrative health data in Saskatchewan, Canada: A retrospective cohort study
Download2015
Kosteniuk, Julie G., Crossley, Margaret, Teare, Gary F., Stewart, Norma J., Quail, Jacqueline M., Kirk, Andrew, Bello-Haas, Vanina Dal, O’Connell, Megan E., Forbes, Dorothy A., Morgan, Debra G., Innes, Anthea
Background Determining the epidemiology of dementia among the population as a whole in specific jurisdictions – including the long-term care population–is essential to providing appropriate care. The objectives of this study were to use linked administrative databases in the province of...
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2007
Forbes, D.A., Wood, J., Morgan, D., Taylor, B., Markle-Reid, M., Forbes, S.C.
This is the protocol for a review and there is no abstract. The objectives are as follows: 1.To evaluate the effects of physical activity programs on function (e.g., activities of daily [ADLs], physical function), cognition, mood, behaviour, and mortality in older persons with dementia. 2.To...
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2008
Morgan, D., Wood, J., Culum, I., Markle-Reid, M., Forbes, S.C., Forbes, D.A.
Background. There is some evidence that physical activity delays the onset of dementia in healthy older adults and slows down cognitive decline to prevent the onset of cognitive disability. Studies using animal models suggest that physical activity has the potential to attenuate the...