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Function and Regulation of TRPP2 and TRPP3, and identification of pore gates of TRP channels
DownloadSpring 2017
The transient receptor potential (TRP) superfamily of cation channels is composed of eight subfamilies, TRPC/V/M/P/ML/A/N/Y, and play distinct sensory roles in response to various environmental stimuli. TRPP2, or polycystin-2, is mutated in autosomal dominant polycystic kidney disease (ADPKD)....
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Spring 2013
Autosomal dominant polycystic kidney disease (ADPKD) is an inherited genetic disorder, inducing cysts in kidney, liver and pancreas. It is caused by pathogenic mutations in the PKD1 or PKD2 gene encoding PKD1 or PKD2 respectively. Cellular abnormalities in ADPKD include cell over-proliferation...
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