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- 2Chan, Catherine B.
- 2Joseph, Jamie W.
- 2Saleh, Monique C.
- 2Wheeler, Michael B.
- 1Koshkin, Vasilij
- 1Lowell, Bradford B.
Chronic exposure to elevated free fatty acids (lipotoxicity) induces uncoupling protein (UCP2) in the pancreatic β-cell, and therefore a causal link between UCP2 and β-cell defects associated with obesity may exist. Recently, we showed that lipid treatment in vivo and in vitro in UCP2(–/–)...
Inhibition of Kv2.1 voltage-dependent K+ channels in pancreatic ß-cells enhances glucose-dependent insulin secretionDownload
Chan, Catherine B., Wang, Jianli, Sakellaropoulos, George, Tsushima, Robert G., Joseph, Jamie W., Smukler, Simon R., Sewing, Sabine, Saleh, Monique C., Wang, Jing, Salapatek, Anne Marie F., Wheeler, Michael B., MacDonald, Patrick E.
Voltage-dependent (Kv) outward K+ currents repolarize β-cell action potentials during a glucose stimulus to limit Ca2+ entry and insulin secretion. Dominant-negative “knockout” of Kv2 family channels enhances glucose-stimulated insulin secretion. Here we show that a putative Kv2.1 antagonist...