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Skip to Search Results- 19Proctor, Spencer D.
- 8Vine, Donna F.
- 6Field, Catherine J.
- 6Mangat, Rabban
- 5Wang, Ye
- 4Borthwick, Faye
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Vaccenic acid suppresses intestinal inflammation by increasing the endocannabinoid anandamide and non-cannabinoid signaling molecules in a rat model of the metabolic syndrome
Download2016
Jacome-Sosa, Miriam, Proctor, Spencer D., Field, Catherine J., Vacca, Claudia, Nelson, Randy C., Mangat, Rabban, Reaney, Martin J., Curtis, Jonathan M., Banni, Sebastiano, Diane, Abdoulaye, Piomelli, Daniele, Igarash, Miki, Vine, Donna F., Shen, Jianheng
Vaccenic acid (VA), the predominant ruminant-derived trans fat in the food chain, ameliorates hyperlipidemia, yet mechanisms remain elusive. We investigated whether VA could influence tissue endocannabinoids (ECs) by altering the availability of their biosynthetic precursor, arachidonic acid...
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Cardiomyocyte antihypertrophic effect of adipocyte tissue conditioned medium from rats and its abrogation by obesity is mediated by the leptin to adiponectin ratio
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Karmazyn, Morris, Proctor, Spencer D., Mangat, Rabban, Gan, Xiaohong T., Bairwa, Suresh C., Rajapurohitam, Venkatesh
White adipocytes are known to function as endocrine organs by secreting a plethora of bioactive adipokines which can regulate cardiac function including the development of hypertrophy. We determined whether adipose tissue conditioned medium (ATCM) generated from the epididymal regions of normal...
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Differential expression of hypothalamic metabolic and inflammatory genes in response to short-term calorie restriction in juvenile obese- and lean-prone JCR rats
Download2015
Vine, Donna F., Jacobs, Rene, Pierce, W.D., Heth, C.D., Russell, Jim, Proctor, Spencer D., Borthwick, Faye, Nelson, Randy, Diane, Abdoulaye, Mangat, Rabban
Background: Childhood obesity is an important early predictor of adult obesity and associated comorbidities. Common forms of obesity are underpinned by both environmental and genetic factors. However, the rising prevalence of obesity in genetically stable populations strongly suggests that...
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Emerging pathways in the regulation of whole body cholesterol flux: Therapeutic opportunities to target atherosclerosis?
Download2014
Mangat, Rabban, Proctor, Spencer D.
INTRODUCTION: CVD remains one of the most frequent causes of morbidity and mortality globally. Increased awareness of lifestyle factors (nutrition/exercise), as well as the refinement of lipid-lowering therapies, has availed some progress in reducing the incidence of CVD. Historically, the...
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Insulin and testosterone are associated with elevated intestinal secretion of lipids and lipoproteins in a rodent model of the metabolic and polycystic ovary syndrome
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Wang, Ye, Shi, Danni, Proctor, Spencer D., Vine, Donna F.
The metabolic syndrome is highly associated with the incidence of Polycystic Ovary Syndrome (PCOS). The metabolic aberrations of insulin resistance and hyperandrogenemia have been proposed to contribute to the development of dyslipidemia and increased Cardiovascular Disease (CVD) risk in PCOS....
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Improving beef hamburger quality and fatty acid profiles through dietary manipulation and exploitation of fat depot heterogeneity
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Dugan, Michael E. R., Rolland, David C., Uttaro, Bethany, Aalhus, Jennifer L., Block, Hushton C., Vahmani, Payam, Mapiye, Cletos, Proctor, Spencer D., McAllister, Timothy A.
Background Hamburger is the most consumed beef product in North America, but lacks in nutritional appeal due to its high fat content and high proportion of saturated fatty acids (SFA). Objectives of the present study were to improve the FA profiles of hamburgers made with perirenal fat (PRF) and...
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Down-regulation of hypothalamic pro-opiomelanocortin (POMC) expression after weaning is associated with hyperphagia-induced obesity in JCR rats overexpressing neuropeptide Y
Download2013
Diane, Abdoulaye, Pierce, W. David, Richard, Denis, Heth, C. Donald, Proctor, Spencer D., Vine, Donna F., Russell, James C.
We hypothesised that hypothalamic feeding-related neuropeptides are differentially expressed in obese-prone and lean-prone rats and trigger overeating-induced obesity. To test this hypothesis, in the present study, we measured energy balance and hypothalamic neuropeptide Y (NPY) and...
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Current issues surrounding the definition of trans-fatty acids: Implications for health, industry and food labels
Download2013
The definition of trans-fatty acids (TFA) was established by the Codex Alimentarius to guide nutritional and legislative regulations to reduce TFA consumption. Currently, conjugated linoleic acid (CLA) is excluded from the TFA definition based on evidence (primarily preclinical studies) implying...
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Dietary fish oil reduces glomerular injury and improves elevated renal hydroxyeicosatetraenoic acid levels in the JCR:LA-cp rat, a model of the metabolic syndrome
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Proctor, Spencer D., Borthwick, Faye, Lu, Jing, Aukema, Harold
We have previously shown nutritional intervention with fish oil (n-3 PUFA) to reduce numerous complications associated with the metabolic syndrome (MetS) in the JCR:LA-corpulent (cp) rat. In the present study, we sought to explore the potential role of fish oil to prevent glomerulosclerosis in...
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Arterial retention of remnant lipoproteins ex-vivo is increased during insulin resistance due to increased arterial biglycan and production of cholesterol-rich atherogenic particles, that can be improved by ezetimibe in the JCR:LA-cp rat
Download2012
Russell, James C., Proctor, Spencer D., Uwiera, Richard R. E., Vine, Donna F., Mangat, Rabban, Hassanali, Zahra, Cheeseman, Christopher I., Borthwick, Faye, Warnakula, Samantha
Background Literature supports the “response-to-retention” hypothesis—that during insulin resistance, impaired metabolism of remnant lipoproteins can contribute to accelerated cardiovascular disease progression. We used the JCR:LA-cp rat model of metabolic syndrome (MetS) to determine the extent...