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Metabolic Engineering of Central Carbon Metabolism for Production of Isobutanol and other Higher Alcohol Biofuels in Saccharomyces cerevisiaeDownload
The yeast Saccharomyces cerevisiae was engineered for production of high-value alcohols including isobutanol and isopentanol. This strategy uses the host’s highly active valine amino acid biosynthetic pathway and diverts its 2-ketoacid intermediate for alcohol synthesis. A 2-ketoacid...