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Skip to Search Results- 17Harding, John C. S.
- 9Plastow, Graham S.
- 5Dekkers, Jack C. M.
- 5Ladinig, Andrea
- 5Lunney, Joan K.
- 4Bao, Hua
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Putting the microbiota to work: Epigenetic effects of early life antibiotic treatment are associated with immune-related pathways and reduced epithelial necrosis following Salmonella Typhimurium challenge in vitro
Download2020-04-01
Costa, Matheus O., Fouhse, Janelle, Silva, Ana Paula P., Wiling, Benjamin, Harding, John C. S.
Salmonella enterica serovar Typhimurium is an animal welfare and public health concern due to its ability to parasite livestock and potentially contaminate pork products. To reduce Salmonella shedding and the risk of pork contamination, antibiotic therapy is used and can contribute to...
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Fetal Metabolomic Alterations Following Porcine Reproductive and Respiratory Syndrome Virus Infection
Download2020-12-11
Malgarin, Carolina M., MacPhee, Daniel J., Harding, John C. S.
PRRSV infection in third-trimester pregnant sows can lead to fetal death and abortions, although the mechanisms triggering these effects are not well understood. Since resistant and susceptible fetuses can coexist in the same litter, we propose that there may be differential mechanisms used by...
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Differential responses in placenta and fetal thymus at 12 days post infection elucidate mechanisms of viral level and fetal compromise following PRRSV2 infection
Download2020-01-01
Van Goor, Angelica, Pasternak, Alex, Walker, Kristen, Hong, Linjun, Malgarin, Carolina, MacPhee, Daniel J., Harding, John C. S., Lunney, Joan K.
Background:A pregnant gilt infected with porcine reproductive and respiratory syndrome virus (PRRSV) can transmit the virus to her fetuses across the maternal-fetal-interface resulting in varying disease outcomes. However,the mechanisms leading to variation in fetal outcome in response to PRRSV...
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Exploring Phenotypes for Disease Resilience in Pigs Using Complete Blood Count Data From a Natural Disease Challenge Model
Download2020-01-01
Bai, Xuechun, Putz, Austin M., Wang, Zhiquan, Fortin, Frederic, Harding, John C. S., Dyck, Michael K., Dekkers, Jack C. M., Field, Catherine J., Plastow, Graham S., PigGen Canada
Disease resilience is a valuable trait to help manage infectious diseases in livestock. It is anticipated that improved disease resilience will sustainably increase production efficiency, as resilient animals maintain their performance in the face of infection. The objective of this study was to...
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The genetic basis of natural antibody titersof young healthy pigs and relationshipswith disease resilience
Download2020-01-01
Chen, Yulu, Tibbs Cortes, Laura E., Ashley, Carolyn, Putz, Austin M., Lim, Kyu-Sang, Dyck, Michael K., Fortin, Frederic, Plastow, Graham S., Dekkers, Jack C. M., Harding, John C. S., PigGen Canada
Background Disease resilience is the ability to maintain performance under pathogen exposure but is difficult to select for because breeding populations are raised under high health. Selection for resilience requires a trait that is heritable, easy to measure on healthy animals, and genetically...
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Genomic Analysis of IgG Antibody Response to Common Pathogens in Commercial Sows in Health-Challenged Herds
Download2020-10-23
Sanglard, Leticia P., PigGen Canada, Mote, Benny E., Willson, Philip, Harding, John C. S., Plastow, Graham S., Dekkers, Jack C. M., Serao, Nick V. L.
Losses due to infectious diseases are one of the main factors affecting productivity in the swine industry, motivating the investigation of disease resilience-related traits for genetic selection. However, these traits are not expected to be expressed in the nucleus herds, where selection is...
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Maternal and fetal thyroid dysfunction following porcine reproductive and respiratory syndrome virus2 infection
Download2020-01-01
Pasternak, J. Alex, MacPhee, Daniel J., Harding, John C. S.
To better understand the host response to porcine reproductive and respiratory virus-2 (PRRSV2) we evaluated circulating thyroid hormone and associated gene expression in a late gestation challenge model. Pregnant gilts were inoculated at gestation day 85 and fetal samples collected at either 12...
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Novel Resilience Phenotypes Using Feed Intake Data From a Natural Disease Challenge Model in Wean-to-Finish Pigs
Download2019-01-01
Putz, Austin M., Harding, John C. S., Dyck, Michael K., Fortin, F., Plastow, Graham S., Dekkers, Jack C. M., PigGen Canada
The objective of this study was to extract novel phenotypes related to disease resilience using daily feed intake data from growing pigs under a multifactorial natural disease challenge that was designed to mimic a commercial environment with high disease pressure to maximize expression of...
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RESEARCHOpen AccessDevelopment of a 3D printed device tosupport long term intestinal culture as analternative to hyperoxic chamber methods
Download2017-01-01
Costa, Matheus O., Nosach, Roman, Harding, John C. S.
Background:Most interactions between pathogenic microorganisms and their target host occur on mucosal surfaces of internal organs such as the intestine. In vitro organ culture (IVOC) provides an unique tool for studyinghost-pathogen interactions in a controlled environment. However, this...
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Type 2 porcine reproductive and respiratory syndrome virus infection increases apoptosis at the maternal-fetal interface in late gestation pregnant gilts
Download2017-03-01
Novakovic, Predrag, Harding, John C. S., Al-Dissi, Ahmad N., Detmer, Susan E.
The pathogenesis of fetal death associated with porcine reproductive and respiratory syndrome (PRRS) is hypothesized to be a consequence of PRRS virus-induced apoptosis at the maternal-fetal interface (MFI). The objectives of this study were to evaluate distribution and degree of apoptosis in the...