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- 39Field, Catherine J.
- 6Proctor, Spencer D.
- 6Ruth, Megan R.
- 5Goruk, Susan
- 4Azad, Meghan B.
- 4Bell, Rhonda C.
n-3 fatty acids inhibit transcription of human IL-13: Implications for development of T helper type 2 immune responsesDownload
Fish oil supplementation during pregnancy has been associated with lower levels of cord blood IL-13, suggesting that the administration of n-3 fatty acids may attenuate the development of allergic disease. The present study aimed to investigate the mechanism by which n-3 fatty acid administration...
Vaccenic and elaidic acid modify plasma and splenocyte membrane phospholipids and mitogen-stimulated cytokine production in obese insulin resistant JCR:LA-cp ratsDownload
This study assessed the long-term effects of dietary vaccenic acid (VA) and elaidic acid (EA) on plasma and splenocyte phospholipid (PL) composition and related changes in inflammation and splenocyte phenotypes and cytokine responses in obese/insulin resistant JCR:LA-cp rats. Relative to lean...
Vaccenic acid suppresses intestinal inflammation by increasing the endocannabinoid anandamide and non-cannabinoid signaling molecules in a rat model of the metabolic syndromeDownload
Jacome-Sosa, Miriam, Proctor, Spencer D., Field, Catherine J., Vacca, Claudia, Nelson, Randy C., Mangat, Rabban, Reaney, Martin J., Curtis, Jonathan M., Banni, Sebastiano, Diane, Abdoulaye, Piomelli, Daniele, Igarash, Miki, Vine, Donna F., Shen, Jianheng
Vaccenic acid (VA), the predominant ruminant-derived trans fat in the food chain, ameliorates hyperlipidemia, yet mechanisms remain elusive. We investigated whether VA could influence tissue endocannabinoids (ECs) by altering the availability of their biosynthetic precursor, arachidonic acid...
Vaccenic acid (VA) is a ruminant-derived trans-fat and precursor of conjugated linoleic acid (CLA). The objective of the present study was to explore the effects of VA on immune function in a model of the metabolic syndrome, JCR:LA-cp rats. Lean (2:1 mix of +/cp and +/+) and obese (cp/cp) rats,...
Background Hemodialysis patients are at risk for deficiency of essential trace elements and excess of toxic trace elements, both of which can affect health. We conducted a systematic review to summarize existing literature on trace element status in hemodialysis patients. Methods All studies...
Kinniburgh, David, Bello, Aminu K., Walsh, Michael, Wiebe, Natasha, Manns, Braden J., Field, Catherine J., Thompson, Stephanie, Faruque, Labib, Hemmalgarn, Brenda R., Klarenbach, Scott W., Tonelli, Marcello
Background People with kidney failure are often deficient in zinc and selenium, but little is known about the optimal way to correct such deficiency. Methods We did a double-blind randomized trial evaluating the effects of zinc (Zn), selenium (Se) and vitamin E added to the standard oral renal...
Estimating dietary choline intake can be challenging due to missing foods in the current United States Department of Agriculture (USDA) database. The objectives of the study were to quantify the choline-containing moieties and the total choline content of a variety of pulses available in North...
The modifying effects of galactomannan of Canadian-grown fenugreek (Trigonella foenum-graecum L) on the glycemic and lipidemic staus in ratsDownload
Using high sucrose-fed male Sprague-Dawley rats, a study was conducted to determine the effects of feeding Galactomannan (GAL), a soluble dietary fiber extracted from Canadian-grown fenugreek seeds, on blood lipid and glucose responses. Rats (n = 8, 175–200 g) were randomly assigned to one of...
The intestine and the gut-associated lymphoid tissue (GALT) are essential components of whole body immune defense, protecting the body from foreign antigens and pathogens, while allowing tolerance to commensal bacteria and dietary antigens. The requirement for protein to support the immune system...
The current recommended vitamin D intake guideline for diet and supplements during pregnancy is not adequate to achieve vitamin D sufficiency for most pregnant womenDownload
Background The aims of this study were to determine if pregnant women consumed the recommended vitamin D through diet alone or through diet and supplements, and if they achieved the current reference range vitamin D status when their reported dietary intake met the current recommendations....