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- 2Dieleman, Levinus
- 2Gänzle, Michael G.
- 2Valcheva, Rosica
- 1Baracos, Vickie
- 1Farhangfar, Arazm
- 1Koleva, Petya
The role of intestinal microbiota in development of irinotecan toxicity and in toxicity reduction through dietary fibres in ratsDownload
CPT-11 is a drug used as chemotherapy for colorectal cancer. CPT-11 causes toxic side-effects in patients. CPT-11 toxicity has been attributed to the activity of intestinal microbiota, however, intestinal microbiota may also have protective effects in CP!-11 chemotherapy. This study aimed to...
Inulin and fructo-oligosaccharides have divergent effects on colitis and commensal microbiota in HLA-B27 transgenic ratsDownload
Modulation of intestinal microbiota by non-digestible carbohydrates may reduce inflammation in inflammatory bowel disease (IBD). The aim of the present study was to assess the effects of inulin and fructo-oligosaccharides (FOS) on intestinal microbiota and colitis in HLA-B27 transgenic rats, a...