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Skip to Search Results- 20Chan, Catherine B.
- 7Wheeler, Michael B.
- 4Koshkin, Vasilij
- 3Bell, Rhonda C.
- 2Adisakwattana, Sirichai
- 2Dai, Feihan F.
- 5Bioenergetics
- 5Metabolism
- 3Physical Activity
- 2Adipose Tissue
- 2Advanced Glycation End Products
- 2Diabetes
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2003
Chan, Catherine B., Wang, Xiaolin, Koshkin, Vasilij, Wheeler, Michael B., Scherer, Philipp E.
Excessive free fatty acid (FFA) exposure represents a potentially important diabetogenic condition that can impair insulin secretion from pancreatic β-cells. Because mitochondrial oxidative phosphorylation is a main link between glucose metabolism and insulin secretion, in the present work we...
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Assessment of the mechanisms exerting glucose-lowering effects of dried peas in glucose-intolerant rats
Download2012
Jin, Alena, Field, Catherine J., Yee, Homun, Kozicky, Lisa, Morris, Jill, Chan, Catherine B., Bell, Rhonda C., Ha, Christine, Whitlock, Kevin A., Ozga, Jocelyn A.
The present study compared the effects of feeding uncooked pea fractions (embryo v. seed coat) on glucose homeostasis in glucose-intolerant rats and examined potential mechanisms influencing glucose homeostasis. Rats were made glucose intolerant by high-fat feeding, after which diets containing...
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The reliability and validity of the perceived dietary adherence questionnaire for people with type 2 diabetes
Download2015
Soria-Contreras, Diana C., Xu, Yunke, Asaad, Ghada, Sadegian, Maryam, Lau, Rita, Chan, Catherine B., Bell, Rhonda C.
Nutrition therapy is essential for diabetes treatment, and assessment of dietary intake can be time consuming. The purpose of this study was to develop a reliable and valid instrument to measure diabetic patients’ adherence to Canadian diabetes nutrition recommendations. Specific information...
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IL-6 indirectly modulates the induction of glyceroneogenic enzmes in adipose tissue during exercise
Download2012
Wan, Zhongxiao, Beaudoin, Marie-Soleil, Castellani, Laura, Wright, David C., Ritchie, Ian, Chan, Catherine B.
Background Glyceroneogenesis is an important step in the control of fatty acid re-esterification with PEPCK and PDK4 being identified as key enzymes in this process. We have previously shown that glyceroneogenic enzymes such as PDK4 are rapidly induced in white adipose tissue during exercise....
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Limited mitochondrial permeabilization is an early manifestation of palmitate-induced lipotoxicity in pancreatic ß-cells
Download2008
Wheeler, Michael B., Chan, Catherine B., Dai, Feihan F., Koshkin, Vasilij, Robson-Doucette, Christine A.
Involvement of the mitochondrial permeability transition (MPT) pore in early stages of lipotoxic stress in the pancreatic β-cell lines MIN6 and INS-1 was the focus of this study. Both long term (indirect) and acute (direct) effects of fatty acid (FA) application on β-cell susceptibility to...
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Isoferulic acid prevents methylglyoxal-induced protein glycation and DNA damage by free radical scavenging activity
Download2015
Sompong, Weerachat, Suantawee, Tanyawan, Thilavech, Thavaree, Adisakwattana, Sirichai, Meeprom, Aramsri, Chan, Catherine B.
Background Isoferulic acid (IFA), a naturally occurring cinnamic acid derivative, is a main active ingredient of the rhizoma of Cimicifuga dahurica. It has been shown various pharmacological activities. The aim of the study was to investigate the effect of IFA against MG-induced protein glycation...
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Collective knowledge: Using a consensus conference approach to develop recommendations for physical activity and nutrition programs for persons with type 2 diabetes
Download2012
Bell, Rhonda C., Walker, Jessica, Chan, Catherine B., Berry, Tanya R.
The purpose of this consensus conference was to have a lay panel of persons with type 2 diabetes (T2D) work in collaboration with an expert panel of diabetes professionals to develop strategies designed to improve dietary and physical activity adherence in persons with T2D. Lay panel participants...
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Inhibition of Kv2.1 voltage-dependent K+ channels in pancreatic ß-cells enhances glucose-dependent insulin secretion
Download2002
Chan, Catherine B., Wang, Jianli, Sakellaropoulos, George, Tsushima, Robert G., Joseph, Jamie W., Smukler, Simon R., Sewing, Sabine, Saleh, Monique C., Wang, Jing, Salapatek, Anne Marie F., Wheeler, Michael B., MacDonald, Patrick E.
Voltage-dependent (Kv) outward K+ currents repolarize β-cell action potentials during a glucose stimulus to limit Ca2+ entry and insulin secretion. Dominant-negative “knockout” of Kv2 family channels enhances glucose-stimulated insulin secretion. Here we show that a putative Kv2.1 antagonist...
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The characterization of mitochondrial permeability transition (MPT) in clonal pancreatic beta cells: Multiple modes and regulation
Download2004
Chan, Catherine B., Bikopoulos, George, Koshkin, Vasilij, Wheeler, Michael B.
Mitochondrial permeability transition (MPT), which contributes substantially to the regulation of normal mitochondrial metabolism, also plays a crucial role in the initiation of cell death. It is known that MPT is regulated in a tissue-specific manner. The importance of MPT in the pancreatic...
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Transcriptional regulation of lipid metabolism: A key determinant of pancreatic ß-cell function
Download2005
Fatehi-Hassanabad, Zahra, Chan, Catherine B.
Background Optimal pancreatic β-cell function is essential for the regulation of glucose homeostasis in both humans and animals and its impairment leads to the development of diabetes. Type 2 diabetes is a polygenic disease aggravated by environmental factors such as low physical activity or a...