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Skip to Search Results- 21Chan, Catherine B.
- 7Wheeler, Michael B.
- 4Koshkin, Vasilij
- 3Bell, Rhonda C.
- 2Adisakwattana, Sirichai
- 2Dai, Feihan F.
- 5Bioenergetics
- 5Metabolism
- 3Nutrition
- 3Physical Activity
- 2Adipose Tissue
- 2Advanced Glycation End Products
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Isoferulic acid prevents methylglyoxal-induced protein glycation and DNA damage by free radical scavenging activity
Download2015
Sompong, Weerachat, Suantawee, Tanyawan, Thilavech, Thavaree, Adisakwattana, Sirichai, Meeprom, Aramsri, Chan, Catherine B.
Background Isoferulic acid (IFA), a naturally occurring cinnamic acid derivative, is a main active ingredient of the rhizoma of Cimicifuga dahurica. It has been shown various pharmacological activities. The aim of the study was to investigate the effect of IFA against MG-induced protein glycation...
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Collective knowledge: Using a consensus conference approach to develop recommendations for physical activity and nutrition programs for persons with type 2 diabetes
Download2012
Bell, Rhonda C., Walker, Jessica, Chan, Catherine B., Berry, Tanya R.
The purpose of this consensus conference was to have a lay panel of persons with type 2 diabetes (T2D) work in collaboration with an expert panel of diabetes professionals to develop strategies designed to improve dietary and physical activity adherence in persons with T2D. Lay panel participants...
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Inhibition of Kv2.1 voltage-dependent K+ channels in pancreatic ß-cells enhances glucose-dependent insulin secretion
Download2002
Chan, Catherine B., Wang, Jianli, Sakellaropoulos, George, Tsushima, Robert G., Joseph, Jamie W., Smukler, Simon R., Sewing, Sabine, Saleh, Monique C., Wang, Jing, Salapatek, Anne Marie F., Wheeler, Michael B., MacDonald, Patrick E.
Voltage-dependent (Kv) outward K+ currents repolarize β-cell action potentials during a glucose stimulus to limit Ca2+ entry and insulin secretion. Dominant-negative “knockout” of Kv2 family channels enhances glucose-stimulated insulin secretion. Here we show that a putative Kv2.1 antagonist...
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The characterization of mitochondrial permeability transition (MPT) in clonal pancreatic beta cells: Multiple modes and regulation
Download2004
Chan, Catherine B., Bikopoulos, George, Koshkin, Vasilij, Wheeler, Michael B.
Mitochondrial permeability transition (MPT), which contributes substantially to the regulation of normal mitochondrial metabolism, also plays a crucial role in the initiation of cell death. It is known that MPT is regulated in a tissue-specific manner. The importance of MPT in the pancreatic...
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Transcriptional regulation of lipid metabolism: A key determinant of pancreatic ß-cell function
Download2005
Fatehi-Hassanabad, Zahra, Chan, Catherine B.
Background Optimal pancreatic β-cell function is essential for the regulation of glucose homeostasis in both humans and animals and its impairment leads to the development of diabetes. Type 2 diabetes is a polygenic disease aggravated by environmental factors such as low physical activity or a...
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2014
Mager, Diana R., Chan, Catherine B., Ambler, Kathryn, Salawi, Hebah, Padwal, Rajdeep S., Ball, Geoff D. C.
Background Severe obesity (SO) in pediatrics has become increasing prevalent in recent decades. The objective of our study was to examine differences in demographic, anthropometric, cardiometabolic, and lifestyle variables in children and youth with SO versus their less overweight/obese (OW/OB)...
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Relationship between objective measures of physical activity and weather: A longitudinal study
Download2006
Ryan, Daniel A. J., Chan, Catherine B., Tudor-Locke, Catrine
Background The weather may be a barrier to physical activity but objective assessment of this hypothesis is lacking. Therefore we evaluated the effect of temperature, rain or snow, and wind speed on the daily physical activity of adults. Methods This report contains data from 25 males (BMI (mean...
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Expression of PPARα modifies fatty acid effects on insulin secretion in uncoupling protein-2 knockout mice
Download2007
Fatehi-Hassanabad, Zahra, Chan, Catherine B.
Aims/hypothesis In uncoupling protein-2 (UCP2) knockout (KO) mice, protection of beta cells from fatty acid exposure is dependent upon transcriptional events mediated by peroxisome proliferator-activated receptor-α (PPARα). Methods PPARα expression was reduced in isolated islets from UCP2KO and...
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Acculturation, dietary acceptability and diabetes management among Chinese in North America
Download2013
Zhang, Anran, Chan, Catherine B., Deng, Feiyue
Immigrants to a new country face many challenges when diagnosed with type 2 diabetes, a chronic disease with a complex treatment involving both medical and behavioral interventions. These challenges will depend upon the extent to which the patient has adapted to the new country’s social and...