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- 2Al Sayah, Fatima
- 1Adams, Denise
- 1Cobban, Sandra J
- 1Colmers, Isabelle N.
- 1Conter, Henry J
Background: Overviews of reviews of healthcare interventions (overviews) compile information from multiple systematic reviews (SRs) to provide a single synthesis of relevant evidence for health-care decision-making. Their increasing popularity, combined with a lack of evidence-based guidance for...
Patient-reported outcome measures for adverse events: A systematic review and COSMIN evaluation studyDownload
ABSTRACT Background: Health care requires constant improvement. Harms in health care are becoming a priority, as is incorporating the patient’s voice in both clinical research and clinical care. Patients have been found to provide a more subjective, detailed perspective of their treatment...
Background: There is emerging evidence that randomized trials are subject to biases. Flaws in the design of such trials can result in over- or underestimation of the treatment effect size. Aim: To examine the empirical evidence for bias, to quantify the extent of bias associated with methodology,...
Introduction Systematic reviews (SRs) synthesize published and sometimes unpublished data and are often based on randomized controlled trials (RCTs). However, RCTs are known to be poor at identifying and reporting harms. The PRISMA (Preferred Reporting Items for Systematic Reviews and...
The Effectiveness of Cognitive Behavioural Therapy for Secondary Prevention of Coronary Heart Disease: A Meta-AnalysisDownload
The effectiveness of secondary prevention (SP) for coronary heart disease (CHD) is well established. The poor integration of evidence into clinical practice remains problematic, in part due to the poor description of trials evaluating these programs. As a result, knowledge users remain unclear...
Background: The prevalence of dementia, a progressive and incurable condition that affects memory and daily function, is increasing worldwide. The perspective of people with dementia can be captured to better understand which factors impact quality of life for this particular population. Such...
Work engagement in nursing practice is critically important to consider in addressing key challenges of health systems, including the global nursing shortage, pressures to reduce health care spending, and increasing demands for quality care and positive outcomes for patients. There is a...
Background: N-of-1 trials are prospectively planned, multiple crossover evaluations, conducted in individual patients. Evidence shows that a range of designs and statistical methods have been applied to N-of-1 trials. This thesis helps to provide a comprehensive understanding about the...
The Experiences of Advanced Placement and International Baccalaureate Diploma Program Participants: A Systematic Review of Qualitative ResearchDownload
Enriched high school curricula like the Advanced Placement and International Baccalaureate Diploma programs are endorsed as enhanced entry programs for postsecondary-bound students. Program participation is perceived to have benefits that appeal to broad stakeholder groups of students, parents...
How the costs of research and its associated risks contribute to a minimum price that would support continued private pharmaceutical investment is unclear. We employed a linear cost-volume-revenue breakeven analysis to equate initial capital investment and risk, and its associated...