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- 2Al Sayah, Fatima
- 1Adams, Denise
- 1Cobban, Sandra J
- 1Colmers, Isabelle N.
- 1Conter, Henry J
Patient-reported outcome measures for adverse events: A systematic review and COSMIN evaluation studyDownload
ABSTRACT Background: Health care requires constant improvement. Harms in health care are becoming a priority, as is incorporating the patient’s voice in both clinical research and clinical care. Patients have been found to provide a more subjective, detailed perspective of their treatment...
How the costs of research and its associated risks contribute to a minimum price that would support continued private pharmaceutical investment is unclear. We employed a linear cost-volume-revenue breakeven analysis to equate initial capital investment and risk, and its associated...
This thesis presents the results of three studies examining the management of migraine in children. First we conducted a systematic review of all clinical trials conducted in children and adolescents of the acute migraine therapy. A meta-analysis of the 26 randomized controlled trials is...
Background: Demographics in residential care facilities for the aged have changed, such that residents are older, more functionally dependent, more cognitively impaired upon admission, and more of the elderly are entering these facilities with some or all of their natural dentition, rather than...
Work engagement in nursing practice is critically important to consider in addressing key challenges of health systems, including the global nursing shortage, pressures to reduce health care spending, and increasing demands for quality care and positive outcomes for patients. There is a...
Introduction Systematic reviews (SRs) synthesize published and sometimes unpublished data and are often based on randomized controlled trials (RCTs). However, RCTs are known to be poor at identifying and reporting harms. The PRISMA (Preferred Reporting Items for Systematic Reviews and...
Individuals with type 2 diabetes (T2DM) have an increased risk of bladder cancer, relative to non-diabetic individuals. We aimed to investigate factors that may influence this association. Some reports suggest an association between the glucose-lowering drug pioglitazone and bladder cancer. Our...
Efficacy and side-effect profiles of lactulose, docusate sodium, and sennosides compared to PEG in opioid-induced constipation: A systematic reviewDownload
Opioid-induced constipation (OIC) is an unpleasant and ubiquitous side effect of opioid treatment. Ineffective treatment of OIC can result in decreased adherence to opioid therapy, decreased quality of life, and increased morbidity and mortality. The constipating effects of opioids result from...
INTRODUCTION Antioxidant micronutrients may help alleviate oxidative stress in cystic fibrosis (CF) lung disease. To determine treatment effect, systematic reviews (SR) synthesize available evidence. Cochrane SRs are known for being methodologically rigourous, however, may have...
Background: N-of-1 trials are prospectively planned, multiple crossover evaluations, conducted in individual patients. Evidence shows that a range of designs and statistical methods have been applied to N-of-1 trials. This thesis helps to provide a comprehensive understanding about the...