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- 3Positron emission tomography
- 1Affinity and selectivity
- 1Alpha-2 adrenoceptors
Structure-Affinity Relationship Study of Novel Imidazoline Ligands at Imidazoline Binding Sites and α-AdrenoceptorsDownload
Many drugs containing an imidazoline moiety are thought to bind to both imidazoline binding sites (IBS) and α-adrenoceptors (α-AR) to mediate their therapeutic effects. To aid in better characterisation of these binding sites, the structure-affinity relationships of several new series of...
Utilizing Positron Emission Tomography to Detect Functional Changes Following Drug Therapy in a Renal Cell Carcinoma Mouse ModelDownload
Sunitinib is currently the first line drug therapy for metastasizing renal cell carcinoma (RCC). It has been shown to have a profound effect on tumor angiogenesis leading to modifications of the tumor’s microenvironment. Tumor hypoxia plays an important role in the metastatic potential of a solid...
Characterization of transport of positron emission tomography tracer 3′-deoxy-3′-fluorothymidine by nucleoside transportersDownload
Positron emission tomography (PET) tracer 3′-fluoro-3′-deoxythymidine (FLT) is used for imaging tumor proliferation. Prior to this work, human equilibrative nucleoside transporter 1 (hENT1) was the only known human nucleoside transporter (hNT) capable of FLT transport. The aim of this research...