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- 2Finlay, Warren H.
- 2Löbenberg, Raimar
- 1Al-Hallak, M. H. D. Kamal
- 1Arshad, Muhammad
- 1Azarmi, Shirzad
- 1Bachynsky, J.
- 6Graduate Studies and Research, Faculty of
- 6Graduate Studies and Research, Faculty of/Theses and Dissertations
- 3Pharmacy and Pharmaceutical Sciences, Faculty of
- 3Pharmacy and Pharmaceutical Sciences, Faculty of/Journal Articles (Pharmacy)
- 1Chemistry, Department of
- 1Chemistry, Department of/Journal Articles (Chemistry)
The objective of this thesis is to design nanoparticle (NP)-based drug delivery systems suitable for treatment of bone diseases. Two types of nanocarriers, (1) polymer coated bovine serum albumin (BSA) NPs and (2) lipid based NPs (micelles and liposomes) were investigated. The BSA NPs were...
Arsenic trioxide (ATO), dissolved in water as arsenous acid or inorganic arsenite (AsIII), is an effective chemotherapeutic agent against acute promyelocytic leukemia (APL). It has been investigated as a potential treatment for a variety of solid tumors although with much poorer efficacy than for...
Cell-electronic Sensing of Cellular Responses and Toxicity Induced by Nanoparticles and Arsenic SpeciesDownload
We demonstrate the development of a real-time cell analysis (RTCA) platform for studying nanoparticle- and arsenic-induced cytotoxicity with potential applications to risk assessment, environmental toxicity monitoring, and drug development. RTCA is an impedance-based in vitro detection system...
Sustained Drug Release And Antibacterial Activity Of Ampicillin incorporated Poly (methyl methacrylate)-Nylon6 Core/Shell NanofibersDownload
A drug delivery system was designed based on the encapsulation of Ampicillin sodium salt in Poly (methyl methacrylate)(PMMA)-Nylon6 core/shell nanofibers and the release characteristics and antibacterial activity of the system were investigated. It was revealed that the system is capable of...
Poly n-butylcyanoacrylate (PNBCA) nanocapsules as a carrier for NSAIDs: in vitro release and in vivo skin penetrationDownload
Abstract: Purpose: The aim of this work was to prepare poly n-butylcyanoacrylate (PNBCA) nanocapsules loaded with indomethacin and to evaluate the ability of this carrier system to deliver the drug systemically after its topical application. Methods: Poly n-butylcyanoacrylate (PNBCA) nanocapsules...
A device constructed by sandwiching a thin film of poly(N-isopropylacrylamide)-co-acrylic acid (pNIPAmco-AAc) microgels between two thin layers of Au (all on a glass support) was used as a novel platform for controlled release of small molecules (drugs). In this submission, the model drug tris...
The present thesis describes preliminary studies required for evaluating silicon nanocrystals (Si-NCs) as photothermal (PT) therapy agents and drug delivery vehicles. Group 14 semiconductor NCs are of particular interest for these applications because of their tailorable optical response and...