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- 2Berry, Tanya R
- 2Veldhoen, Richard
- 1Alberta Centre for Active Living
- 1Alqahtani,Hind M
- 1Bekele, Raie Taye
- 1Benesch, Matthew GK
- 19Graduate Studies and Research, Faculty of
- 19Graduate Studies and Research, Faculty of/Theses and Dissertations
- 3Kinesiology, Sport, and Recreation, Faculty of
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- 1St. Stephen's College
- 1St. Stephen's College/Department of Psychotherapy and Spirituality (St. Stephen's College)
Breast cancer is the most common cancer and the leading cause of cancer-related death among Canadian women. Despite improvements in treatment and early detection, there is still a need to develop novel therapies for breast cancer management. Aberrant Notch signaling is tumorigenic and is...
MOLECULAR AND PHENOTYPIC CHARACTERIZATION OF DISTINCT BREAST CANCER CELL SUBPOPULATIONS PURIFIED USING A SOX2 REGULATORY REGION 2 TRANSCRIPTION ACTIVITY REPORTERDownload
Sex-determining Region Y-box 2 (Sox2) is a transcription factor integral to the maintenance of pluripotency in embryonic stem cells. In recent years, Sox2 expression has been detected and implicated in the pathogenesis of breast and other cancers. Clinically, Sox2 expression has been associated...
Association mapping of genes using whole genome polymorphism arrays: Identification of markers of breast cancer susceptibility in Alberta womenDownload
Breast cancer is a heterogeneous, polygenic disease and is influenced by genetic, environmental and life-style factors. Many single nucleotide polymorphisms (SNPs) associated with breast cancer risk have been identified in genome-wide association studies (GWASs) by several research groups for...
I have conducted a single-case heuristic study of my engagement with breast cancer and how the collective pressure to think positively affected me. I explore the shadow, or the unrecognized significance, that positive thinking placed upon my healing process. I argue that the tacit implication...
In Canada, approximately 40% of the population will be diagnosed with cancer and 25% will die of this disease. In order to treat cancer more effectively, new prognostic and therapeutic targets need to be discovered. In breast cancer, the BH3 only protein BAD has been shown to correlate with...
Breast cancer (BrCa) is the most common cancer and the leading cause of cancer-related deaths in women worldwide. Current therapies for BrCa are insufficient to cure metastatic disease and are often associated with debilitating side effects that severely deteriorate the quality of patients’...
Increased estrogen receptor expression leads to a novel DNA binding signature which differentiates luminal A and luminal B breast cancersDownload
Eighty percent of all breast cancers are estrogen receptor positive (ER+) and molecular profiling has identified two ER+ subtypes: luminal A and luminal B. The accurate diagnosis of these luminal subtypes is one of the greatest clinical challenges with current gene assays obtaining only 75%...
DDX17 (P72), a Sox2 binding partner, regulates Sox2 to sustain tumorigenic and stem-like properties in a phenotypically distinct subset of estrogen positive breast cancer cellsDownload
Abstract: Sox2, an embryonic stem cell marker, is involved in the pathogenesis of breast cancer (BC). Sox2 expression is associated with a poor clinical outcome in BC patients. Based on the differential Sox2 transcriptional activity, we have identified the two phenotypically distinct cell...
Tamoxifen is the accepted therapy for patients with estrogen receptor α (ERα)−positive breast cancer. However, clinical resistance to tamoxifen, as demonstrated by recurrence or progression on therapy, is frequent and precedes death from metastases. To improve breast cancer treatment it is vital...