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Quantitative analysis of single particle tracking experiments: applying ecological methods in cellular biology
DownloadFall 2010
Single-particle tracking (SPT) is a method used to study the diffusion of various molecules within the cell. SPT involves tagging proteins with optical labels and observing their individual two-dimensional trajectories with a microscope. The analysis of this data provides important information...
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Direction-Dependent Communication Mechanisms in Individual-Based Models of Collective Behaviour
DownloadFall 2014
In this thesis, we study direction-dependent communication mechanisms in individual-based models (IBMs) of collective behaviour. Previously, direction-dependent communication mechanism were incorporated into a non-local hyperbolic PDE model for collective behaviour. The PDE model exhibits...
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Mathematical modelling of the effect of low-dose radiation on the G2/M transition and the survival fraction via the ATM/Chk2 pathway
DownloadSpring 2020
Radiation therapy is an important component of cancer treatment. It consists of applying ionizing radiation to kill cells by damaging their DNA and reducing their ability to reproduce and survive. It is reasonable to think that more radiation causes more damage and kills more cells. However, in...