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Mechanosensory and Sphingolipid Mediators of Inflammatory Signaling in Placental Dysfunction
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Preeclampsia (PE) is a leading cause of maternal and fetal morbidity. Placental dysfunction plays a key role in PE and includes decreased syncytialization and increased inflammation and cell death. Tumor Necrosis Factor alpha (TNF-α) is a key factor in inducing this dysfunction. The controversy...
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Fall 2022
Thermo-reversible hydrogels, or thermogels, are a category of gel-forming materials that are liquid at lower temperatures but turn into gel at higher temperatures. Thermogels are explored for different applications in drug delivery and tissue engineering fields. In this context, the development...
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Affective Inheritance: Traumatic Memory in Nigeria-Biafra War Novels (Critical Introduction) and Circumtrauma (Poetry Collection)
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This dissertation represents the culmination of five years of study on the Nigeria-Biafra War (1967-1970). Circumtrauma is a creative dissertation that explores, through poetry, how narratives of the war are held together by an underlying emotional valence which characterizes and transforms how...
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Fall 2022
The construction industry has constantly been researching and looking forimprovements, and off-site construction has been one of the leading areas due to itsadvantages in controlled stations. A common material in off-site construction has beenCross-Laminated Timber (CLT) due to its...
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Fall 2022
The goal of the thesis is to contribute to advancements in the field of trauma-informed care in, particularly for individuals with a significant history of childhood adversity. This was conducted in three ways: ● Chapter 2 is original research, and an intended article, describing results from a...
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Fall 2022
The work in this Thesis describes significant progress made in the field of frustrated Lewis pairs (FLPs) at the intersection between modern main group chemistry and materials chemistry. Mainly, this work focuses on the use of an intramolecular phosphine-borane FLP (namely, o-iPr2P(C6H4)BCy2 or...
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Non-Invasive Electrical Brain Stimulation: Effects on Cognitive Performance and Cerebral Hemodynamics in Younger Adults and Older Adults: A Scoping Review and Two Experimental Studies
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Clinicians including rehabilitation professionals use a variety of evidence-based behavioural techniques to help improve functioning for adults affected by cognitive and language disorders. In recent years, the use of non-invasive brain stimulation has been studied as a method to augment...
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Disrupting the Repeat Domain in Zebrafish Premelanosome Protein (Pmela) to Probe an Evolutionary Puzzle and Model Pigmentary Glaucoma
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The premelanosome protein (PMEL) is a functional amyloid that provides a scaffold for the even distribution of melanin and provides structure for the organelle that contains them, the melanosome. Mutations in this protein cause a plethora of phenotypes that extend beyond affecting strictly...
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A Relational Ethics Approach to Understanding and Addressing Pain in Correctional Settings: An Interpretive Description
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Background: The assessment and management of pain in forensic settings are complicated by contextual factors, including past experiences with pain, adverse childhood experiences, and mental illness and addiction. Nurses in correctional settings have few tools to rely upon to fully understand and...
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Fall 2022
Ducks are the natural host and reservoir of influenza A virus (IAV). It is currently unknown how ducks can both tolerate and restrict IAV replication. It is likely that ducks have evolved unique transcriptional responses to IAV infection to restrict virus while limiting damage from inflammation,...