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Fall 2020
2-aminoadipic acid (2-AAA) has been identified as an accurate long-term biomarker for the future development of diabetes. An investigation of over 2000 patients found that patients in the upper quartile of initial blood 2-AAA levels showed a 2-4x higher incidence of diabetes development over the...
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Fall 2015
Youssef, Nermeen Hosny Ibrahim
Plasma membrane ATP-sensitive potassium (KATP) channels are found in many excitable cell types where they couple cellular metabolism and membrane excitability. . Studies on KATP deficient mice show that parameters of cardiac mechanical function are similar to those of wild-type mice under basal...
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Spring 2019
Paracrine signaling within the pancreatic islets is important for the normal secretion of insulin and glucagon. As the secretion of insulin and glucagon are central to whole body glucose homeostasis, paracrine signaling in the islet has a role in glucose control. Genetic animal models have shown...