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Fall 2023

Forgie, Keir

Lung transplantation is the gold-standard treatment for eligible patients with end-stage lung disease; however, there is an inadequate supply of high-quality donor lungs for transplant, resulting in a wait-list mortality of 15-30%. Ex-situ Lung Perfusion (ESLP) has become an established means of...

Fall 2023

Hinton, Kristin M

Introduction: Osteosarcoma (OS) is a primary bone malignancy most commonly found in children and adolescents. The 5-year survival rate for OS is 60%, which decreases to 27% when distant metastases are present. Currently no tests are available to identify those patients at risk of metastatic...

Spring 2024

Verhoeff, Kevin KW

Twenty-years ago Shapiro et al. revolutionized islet transplantation (ITx), realizing the potential for a cell-based diabetes treatment. Despite improvements, ITx remains restricted by organ donor limitations and immunosuppression. Stem cell (SC)-derived ITx (SC Tx) could eliminate these...

Fall 2024

Williams, Jordana R

The prevalence of oncogenic human papillomavirus (HPV) -related oropharyngeal squamous cell carcinoma (OPSCC) is increasing worldwide. The standard for HPV diagnosis is based on p16 immunohistochemistry (IHC) on tissues, as a surrogate marker for HPV oncogenesis in clinical and trial settings...

Fall 2024

Wagner, Mitchell J.

Each year, roughly 100,000 Canadians are diagnosed with heart failure, a condition that can only be cured by heart transplantation. In recent years, there has been a plateau of heart transplantation volume, thought to be the result of declining donor sources and the bottleneck of short...

Fall 2024

Ma, Zhiyao

Knee osteoarthritis (KOA) is a degenerative joint disease that impacts all structures within the knee joint, often leading to chronic pain and disability. The meniscus, a crucial fibrocartilaginous structure within the knee, plays a key role in joint biomechanics. It is well established that...

Fall 2024

Wong, Jordan M.

Islet transplantation (ITx) is an effective means to restore physiologic glycemic regulation in those living with type 1 diabetes; however, lifelong systemic immunosuppression required to subvert the immune response remains a major barrier to patient inclusion. While these drug therapies delay...

Fall 2024

Mainardi Aguiar da Silva, Guilherme

The number of people suffering from heart failure grows annually. For those people who have advanced heart failure and are eligible for a heart transplant, this is the gold standard procedure to treat them. Allowing not only an improvement in quality of life but also an increase in...