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Spring 2023

Skubleny, Daniel

Five-year overall survival for gastric cancer in Canada is only 25%. Standard of care treatment using neoadjuvant chemotherapy and surgery achieves partial or complete treatment response in only 40% of patients. Additional strategies and methods to discover novel therapies and optimize existing...

Spring 2023

Adegoke, Adeolu

Recent thymic emigrants (RTE) are newly generated T cells that have just been exported to the periphery, where they continue their maturation to become mature T cells. RTE have only undergone central tolerance in the thymus but not yet undergone peripheral tolerance. As such, it is imperative...

Spring 2024

Verhoeff, Kevin KW

Twenty-years ago Shapiro et al. revolutionized islet transplantation (ITx), realizing the potential for a cell-based diabetes treatment. Despite improvements, ITx remains restricted by organ donor limitations and immunosuppression. Stem cell (SC)-derived ITx (SC Tx) could eliminate these...

Fall 2024

Ma, Zhiyao

Knee osteoarthritis (KOA) is a degenerative joint disease that impacts all structures within the knee joint, often leading to chronic pain and disability. The meniscus, a crucial fibrocartilaginous structure within the knee, plays a key role in joint biomechanics. It is well established that...

Fall 2024

Wagner, Mitchell J.

Each year, roughly 100,000 Canadians are diagnosed with heart failure, a condition that can only be cured by heart transplantation. In recent years, there has been a plateau of heart transplantation volume, thought to be the result of declining donor sources and the bottleneck of short...

Fall 2024

Mainardi Aguiar da Silva, Guilherme

The number of people suffering from heart failure grows annually. For those people who have advanced heart failure and are eligible for a heart transplant, this is the gold standard procedure to treat them. Allowing not only an improvement in quality of life but also an increase in...

Fall 2024

Wong, Jordan M.

Islet transplantation (ITx) is an effective means to restore physiologic glycemic regulation in those living with type 1 diabetes; however, lifelong systemic immunosuppression required to subvert the immune response remains a major barrier to patient inclusion. While these drug therapies delay...

Fall 2024

Williams, Jordana R

The prevalence of oncogenic human papillomavirus (HPV) -related oropharyngeal squamous cell carcinoma (OPSCC) is increasing worldwide. The standard for HPV diagnosis is based on p16 immunohistochemistry (IHC) on tissues, as a surrogate marker for HPV oncogenesis in clinical and trial settings...