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Fall 2022

Aggarwal, Saloni

Islet cell transplantation is an effective method to treat type 1 diabetes mellitus, however, significant barriers currently exist preventing its implementation as the gold standard therapy. Of note, cell death in the acute post-transplant period accounts for loss of up to 80% of newly...

Fall 2022

Vyhlidal, Margaret J.

Menisci are fibrocartilaginous structures of the knee that function in mechanical load transmission to protect articular cartilage from forces that may initiate osteoarthritic changes. A population of cells responsible for regulating the tissues’ biomechanical properties are meniscus...

Fall 2022

Shayeganpour, Kasra

Background Intraportal islet transplantation is a suitable method to treat type 1 diabetes. However, this treatment option is limited to a small subpopulation of patients with diabetes. For islet transplantation to be a more sustainable treatment option, major obstacles must be overcome. An...

Spring 2022

Dang, Jerry

BackgroundEvidence is emerging that the gut microbiome is an important contributor to the weight and metabolic effects of bariatric surgery. However, the microbial and intestinal physiological changes that occur with bariatric surgery are poorly understood. Developing this understanding...

Spring 2022

Qi, Xiao

The overall goal of this study is to improve the protocols for Ex Situ heart perfusion (ESHP) to better preserve the function and viability of donated hearts. ESHP has emerged as a new method of donor heart preservation. Unlike the standard cold storage technique, in ESHP, the heart is perfused...

Spring 2023

Danyluk, Hayden J.

Trigeminal Neuralgia (TN) is a chronic, neuropathic, facial pain condition characterized by severe unilateral pain attacks, electric shock-like or shooting in character, confined to regions of the face innervated by the trigeminal nerve (the fifth cranial nerve, CNV). TN is commonly associated...

Fall 2023

Hinton, Kristin M

Introduction: Osteosarcoma (OS) is a primary bone malignancy most commonly found in children and adolescents. The 5-year survival rate for OS is 60%, which decreases to 27% when distant metastases are present. Currently no tests are available to identify those patients at risk of metastatic...

Fall 2023

Forgie, Keir

Lung transplantation is the gold-standard treatment for eligible patients with end-stage lung disease; however, there is an inadequate supply of high-quality donor lungs for transplant, resulting in a wait-list mortality of 15-30%. Ex-situ Lung Perfusion (ESLP) has become an established means of...

Fall 2023

White, Abigail

Simulation-based training is widely adopted amongst surgical specialties that have a minimally invasive approach such as laparoscopic surgery and predominantly open surgical specialties such as cardiac surgery remain in an apprenticeship model. The growing complexity of cases, scrutinized...

Fall 2023

Hefler, Joshua J.

Normothermic machine perfusion (NMP) is a novel method of organ preservation that has recently risen in prominence. NMP involves the maintenance of an organ outside the body to recreate its physiologic milieu, such as by providing oxygen and nutrients and maintaining temperature. We are only just...