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Skip to Search Results- 2Sigalet, David L.
- 2Yamoah, Ebenezer Nketia.
- 1Aboelnazar, Nader Saber
- 1Abualhassan, Nasser
- 1Adegoke, Adeolu
- 1Aggarwal, Saloni
- 7Mesenchymal stem cells
- 7Scars
- 6Diabetes
- 6Islet transplantation
- 5Cerebrovascular spasm--Animal models
- 5Fibroblasts
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Inflammation, Oxidative Stress, Metabolic Inefficiency, And Related Functional Decline of the Heart During Ex-situ Perfusion
DownloadSpring 2021
Normothermic ex-situ heart perfusion (ESHP) is an emergent technique that allows for continued perfusion of the beating heart, supplying required oxygen and nutrients. Also, this technique offers a venue to assess the metabolic and functional viability of the donated heart during the period of...
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Fall 2021
The menisci are a pair of knee joint structures that are wedge-shaped in cross-section and semi-lunar in superior view. They play roles in force distribution that help maintain the health of the articular cartilage. In adults, the menisci can be divided into a fibrous, vascularized outer region...
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Fall 2021
Valvular heart disease (VHD) is a common diagnosis with an approximate prevalence of 2.5% of the total population having moderate to severe VHD [1, 2]. The most common treatment for end-stage VHD is surgical valve replacement with constructs categorized into three classes: mechanical valves,...
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The Role of Repeat Surgical Resection in the Management of Patients with Recurrent Glioblastoma
DownloadFall 2021
The prognosis for patients with recurrent glioblastoma (GBM) is dismal, and the question of whether to offer repeat surgery at the time of recurrence is common. Re-operation in the management of these patients is controversial as there is no randomized evidence of benefit. The first component of...
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Fall 2022
Background: Hypertrophic scars (HTS) are a dermal fibroproliferative disorder that commonly occurs following burn injury. Due to the intricate nature of the wound healing process and an incomplete understanding of the molecular mechanisms involved in HTS formation, current treatments have...
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Dynamic Changes of Monocytes and Chemokine Pathway Signaling During Wound Healing Post-Burn Injury
DownloadSpring 2022
Background:There are over 11 million people hospitalized for burns annually according to the World Health Organization, resulting in painful skin scar contractures and restricted movements, as well as mental and physical stresses. Up to 70% of deep dermal injury result in hypertrophic scars,...
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Spring 2022
Fracture healing involves a fragile continuum from inflammation to repair and finally ends in bone reestablishment. Fractures that fail to heal progress to a state of nonunion, causing sub-stantial morbidity for the individual. Nonunion is one of the most serious complications of frac-ture. In an...
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Neonatal Porcine Islet Xenotransplantation: Non-invasive in vivo imaging and basic islet biology
DownloadFall 2022
Islet transplantation has been proven as a successful clinical therapy for diabetes; however, its widespread use is limited by multiple factors including a shortage of human donors, the need for long term immunosuppression and difficulty with graft monitoring post transplantation. Pig islet...
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Fall 2022
Marfil Garza, Braulio Alejandro
Type 1 diabetes (T1D) is caused by autoimmune-mediated destruction of the insulin-producing β-cells in the pancreatic islets of Langerhans. People with T1D need exogenous insulin to survive, but also to avoid complications from uncontrolled glycemia. Unfortunately, insulin treatment commonly...
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New Insights into the Mechanisms of Vascular Dysfunction in a Young and Aged Septic Murine Model
DownloadFall 2022
Background: Sepsis is a dysregulated response to infection that results in life-threatening organ dysfunction. The elderly are disproportionately affected by sepsis and suffer an alarmingly high mortality rate. We hypothesized that increased mortality in the aged is due to a more highly...