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Skip to Search Results- 2Hegadoren, Kathleen M.
- 1Adu, Medard Kofi
- 1Al-Ghamdi,Mohammad S
- 1Al-Nuaimi, Saleem K
- 1Amritraj, Asha
- 1Amusan, Precious
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Fall 2020
In the perimenopausal period, an event marked by end of menstrual cycle regularity, women are at a greater risk of either experiencing a reoccurrence of a major depressive episode (MDE), or presenting with their first MDE. This risk is greater in women with a history of mood vulnerability related...
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Digital Innovations to Support the Health and Wellbeing of Individuals with Problematic Substance Use and Substance Use Disorder
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This dissertation explores the questions “What technology-based interventions are of most benefit in supporting the health and/or rehabilitation of individuals with substance use disorders? Where and how can they be most effectively embedded in the health system?” Chapter 1 begins with an...
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EFFECTS OF TEMPERATURE ON AMYLOID PRECURSOR PROTEIN (APP) METABOLISM IN CULTURED ASTROCYTES
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Alzheimer’s disease (AD), the most common type of senile dementia, is characterized by the presence of β-amyloid (Aβ)-containing neuritic plaques and tau-positive neurofibrillary tangles and the loss of neurons in specified regions of the brain. Evidence suggests that increased levels/aggregation...
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The Humanization of Rodent Beta-Amyloid: The Aggregative and Toxic Properties of Amino-Terminal Beta-Amyloid Mutations
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Human β-amyloid1-42 (hAβ1-42) peptides are known to self-aggregate into oligomers that contribute to the degeneration of neurons and development of Alzheimer's disease (AD) pathology. Unlike humans, rodents do not develop AD, possibly due to differences in three amino acids (R5G, Y10F and H13R)...
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Self-Report Measures and Mobile Applications for Mental Health – Focusing on Suicidality and Bipolar Disorder – Including App Development and Measure Validation
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This thesis describes studies evaluating the predictive validity of suicide risk assessments, assessment and monitoring of bipolar disorder using mobile app-based self-report questionnaires, the feasibility and criterion validity of novel tools for the evaluation of suicidal ideation and...
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A Study of Potential Plasma Biomarkers of Disease Conversion and Progression in Multiple Sclerosis
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Multiple sclerosis (MS) is a complex and heterogeneous disease of the central nervous system (CNS) characterized by leukocyte infiltration, myelin damage, local gliosis, and axonal injury. Relapsing-remitting MS (RRMS) is the most common disease course. Although the pathogenesis remains unclear,...
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Spatiotemporal characterization of post-stroke myelin density changes and their contribution to functional recovery using a novel label-free in vivo imaging technique
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Myelin is an essential component of nervous system functioning: it supports axonal metabolism, enables saltatory conduction to allow for precise timing across cortical networks to regulate information processing and is increasingly recognized as an integral type of adult experience-dependent...
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Spring 2021
Alcohol use disorder (AUD) is one of the most prevalent, harmful, and costly preventable disorders in the world. AUD is associated with wide-spread structural and functional brain deficits, which are at least partially reversible with sustained abstinence. The most rapid recovery is thought to...
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A multi-methods exploration of shared decision-making, lived experience, and opioid use disorder among emerging adults with anxiety and depression
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Background Anxiety/depression are common in emerging adults and may lead to poor coping strategies such as substance use. Shared decision-making (SDM) occurs when clinicians and patients make health decisions together informed by the best available evidence inclusive of the patient’s...
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Glial Expression of Amyloid Precursor Protein (APP) and its Processing Enzymes in the ANPC Mouse Model
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Alzheimer’s disease (AD) is a complex and progressive neurodegenerative disorder believed to be triggered by the accumulation of β-amyloid (Aβ) peptides derived from the proteolytic processing of amyloid precursor protein (APP). The regions primarily affected in AD brains are the hippocampus and...